PAR-4, dlkb1, Par4, STK11
Par-4 kinase - required for the early A-P polarity of the oocyte and for the repolarization of the oocyte cytoskeleton that defines the embryonic A-P axis
Please see the JBrowse view of Dmel\Lkb1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lkb1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Lkb1 in JBrowse3-54
3-51.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
BrdU incorporation analysis and phosphohistone H3 immunostaining reveal that lkb1 expression does not affect G1/S or G2/M cell cycle progression.
lkb1 induces apoptotic cell death but not cell cycle arrest.
lkb1 regulates organ size of the central nervous system by inducing developmental apoptosis during embryogenesis.
lkb1-induced apoptosis is caspase-dependent.
The tumor-suppressing activity of lkb1 is unrelated to the negative regulation of cell growth control.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities, centrosome abnormalities and spindle abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: lkb1 was identified in a genetic screen for germ-line clone mutants that disrupt the localization of the product of the transgene stauαTub67C.T:Avic\GFP-m6 in the oocyte.
lkb1 is required for early A-P polarity of the oocyte and for the repolarization of the oocyte cytoskeleton that defines the embryonic A-P axis.
Source for merge of: CG9374 anon- EST:Posey135
Source for identity of: lkb1 CG9374
Source for identity of: Lkb1 lkb1
