FlyBase Allele Report: Dmel\Lkb1[UAS.cWa]

General Information

Symbol

Dmel\Lkb1^UAS.cWa

Species

D. melanogaster

Name

FlyBase ID

FBal0265787

Feature type

allele

Associated gene

Dmel\Lkb1

Associated Insertion(s)

Carried in Construct

P{UAS-Lkb1.W}

Also Known As

UAS-LKB1

Key Links

Transgenic product class

cDNA

(Wang et al., 2007)

wild_type

(Wang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Wang et al., 2007)

wild_type

(Wang et al., 2007)

Mutagen

in vitro construct

(Wang et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Lkb1.W}

Cytology

Description

UASt regulatory sequences drive expression of a full length Lkb1 cDNA.

(Wang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Lkb1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Wang et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of lkb1^Scer\UAS.cWa under the control of Scer\GAL4^GMR.PF has little effect on eye morphology or photoreceptor number.

(Wang et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of decreased cell number | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

NOT Enhancer of

Statement

Reference

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of visible | adult stage phenotype of Hsap\MAPT^{R406W.S2A.UAS.0N4R}, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of decreased cell number | adult stage phenotype of Hsap\MAPT^{R406W.S2A.UAS.0N4R}, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is an enhancer of photoreceptor phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

NOT Enhancer of

Statement

Reference

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\MAPT^{R406W.S2A.UAS.0N4R}, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Lkb1^UAS.cWa, Scer\GAL4^GMR.PF is a non-enhancer of photoreceptor phenotype of Hsap\MAPT^{R406W.S2A.UAS.0N4R}, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of lkb1^Scer\UAS.cWa enhances the eye degeneration seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Xenogenetic Interactions

Statement

Reference

Expression of lkb1^Scer\UAS.cWa enhances the eye phenotypes seen when Hsap\MAPT^{R406W.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF, resulting in severe disorganisation of the eye and drastic loss of photoreceptor neurons and surrounding cells.

Expression of lkb1^Scer\UAS.cWa does not enhance the photoreceptor loss phenotype seen when Hsap\MAPT^S2A.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Lkb1^Scer\UAS.cWa

Lkb1^UAS.cWa

lkb1^Scer\UAS.cWa

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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