FlyBase Allele Report: Dmel\par-1[UAS.Tag:MYC]

General Information

Symbol

Dmel\par-1^UAS.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0265783

Feature type

allele

Associated gene

Dmel\par-1

Associated Insertion(s)

Carried in Construct

P{UAS-par-1.MYC}

Also Known As

UAS-PAR-1

Key Links

Transgenic product class

wild_type

(Wang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wang et al., 2007)

Mutagen

in vitro construct

(Wang et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-par-1.MYC}

Cytology

Description

UAS regulatory sequences drive expression of the par-1 α isoform tagged with Tag:MYC.

(Wang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

par-1

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates neurodegenerative disease

modeled by Hsap\APP^695.T.UAS

(Wang et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

(King et al., 2011)

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2012)

abnormal neuroanatomy | P-stage, with Scer\GAL4^ppk.PU

(Bu et al., 2022)

visible | adult stage, with Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2010, Wang et al., 2007)

Phenotype Manifest In

adult mushroom body alpha-lobe, with Scer\GAL4^ey-OK107

(King et al., 2011)

adult mushroom body beta-lobe, with Scer\GAL4^ey-OK107

(King et al., 2011)

dendrite, with Scer\GAL4^ppk.PU

(Bu et al., 2022)

dendritic microtubule, with Scer\GAL4^ppk.PU

(Bu et al., 2022)

eye, with Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2010, Wang et al., 2007)

lamina, with Scer\GAL4^GMR.PF

(Iijima-Ando et al., 2012)

larval dorsal multidendritic neuron ddaC, with Scer\GAL4^ppk.PU

(Bu et al., 2022)

microtubule, with Scer\GAL4^ppk.PU

(Bu et al., 2022)

Detailed Description

Statement

Reference

Expression of par-1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF causes age-dependent and progressive neurodegeneration in the lamina; degeneration in the lamina is undetectable in flies at 3-day old, but is prominent at 10 days old.

(Iijima-Ando et al., 2012)

Expression of par-1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^ey-OK107 disrupts the formation of mushroom body α/β lobes. Abnormal β lobes are more common than disrupted α lobes.

(King et al., 2011)

Expression of par-1^{Scer\UAS.T:Hsap\MYC} in the eye under the control of Scer\GAL4^GMR.PF causes degeneration.

(Iijima-Ando et al., 2010)

Expression of par-1^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF causes eye degeneration.

(Wang et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has visible | adult stage phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has visible | adult stage phenotype, enhanceable by Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has visible | adult stage phenotype, non-enhanceable by Scer\GAL4^GMR.PF/lok^UAS.cPa

(Iijima-Ando et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has visible | adult stage phenotype, suppressible by Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has visible | adult stage phenotype, suppressible by Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Other

Statement

Reference

Scer\GAL4^GMR.PF, milt^GD8116, par-1^UAS.Tag:MYC has abnormal neuroanatomy phenotype

(Iijima-Ando et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has eye phenotype, enhanceable by Lkb1^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has eye phenotype, enhanceable by Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF

(Wang et al., 2007)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/lok^UAS.cPa

(Iijima-Ando et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has eye phenotype, suppressible by Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC has eye phenotype, suppressible by Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Enhancer of

Statement

Reference

Scer\GAL4^ppk.PU/par-1^UAS.Tag:MYC is an enhancer of dendritic microtubule phenotype of Scer\GAL4^ppk.PU, chb^GL00367

(Bu et al., 2022)

Scer\GAL4^ppk.PU/par-1^UAS.Tag:MYC is an enhancer of larval dorsal multidendritic neuron ddaC phenotype of Scer\GAL4^ppk.PU, chb^GL00367

(Bu et al., 2022)

Other

Statement

Reference

Scer\GAL4^GMR.PF, milt^GD8116, par-1^UAS.Tag:MYC has lamina phenotype

(Iijima-Ando et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of par-1^{Scer\UAS.T:Hsap\MYC} and milt^GD8116 under the control of Scer\GAL4^GMR.PF causes prominent neurodegeneration in the lamina at 3 days old.

(Iijima-Ando et al., 2012)

Co-expression of lkb1^Scer\UAS.cWa enhances the eye degeneration seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

Co-expression of lkb1^{dsRNA.Scer\UAS.cWa} suppresses the eye degeneration seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Xenogenetic Interactions

Statement

Reference

Expression of lok^Scer\UAS.cPa does not enhance the eye degeneration phenotype seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

(Iijima-Ando et al., 2010)

Expression of Hsap\APP^{695.T.Scer\UAS} enhances the rough eye phenotype seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

Expression of lkb1^{dsRNA.Scer\UAS.cWa} suppresses the rough eye phenotype seen when par-1^{Scer\UAS.T:Hsap\MYC} and Hsap\APP^{695.T.Scer\UAS} are co-expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

par-1^{Scer\UAS.T:Hsap\MYC}

par-1^UAS.Tag:MYC

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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