FlyBase Allele Report: Dmel\Lkb1[RNAi.UAS.cWa]

General Information

Symbol

Dmel\Lkb1^RNAi.UAS.cWa

Species

D. melanogaster

Name

FlyBase ID

FBal0265788

Feature type

allele

Associated gene

Dmel\Lkb1

Associated Insertion(s)

Carried in Construct

P{UAS-Lkb1.RNAi.W}

Also Known As

UAS-LKB1 RNAi

Key Links

Transgenic product class

RNAi_reagent

(Wang et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Wang et al., 2007)

Mutagen

in vitro construct

(Wang et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Lkb1.RNAi.W}

Cytology

Description

UAS sequences drive expression of full length genomic Lkb1 sequence, (under the control of its own promoter) fused with an inverted Lkb1 cDNA.

(Wang et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Lkb1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates neurodegenerative disease

modeled by Hsap\APP^695.T.UAS, par-1^UAS.Tag:MYC

(Wang et al., 2007)

modeled by Hsap\APP^695.T.UAS, Hsap\MAPT^R406W.UAS

(Wang et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of lkb1^{dsRNA.Scer\UAS.cWa} under the control of Scer\GAL4^GMR.PF has little effect on eye morphology.

(Wang et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Lkb1^RNAi.UAS.cWa is an enhancer of visible | adult stage phenotype of Hsap\APP^695.T.UAS, Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Suppressor of

Statement

Reference

Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF, Lkb1^RNAi.UAS.cWa is an enhancer of eye phenotype of Hsap\APP^695.T.UAS, Hsap\MAPT^UAS.cWa, Scer\GAL4^GMR.PF

(Wang et al., 2007)

Suppressor of

Statement

Reference

Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Lkb1^RNAi.UAS.cWa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\APP^695.T.UAS, Scer\GAL4^GMR.PF, par-1^UAS.Tag:MYC

(Wang et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of lkb1^{dsRNA.Scer\UAS.cWa} suppresses the eye degeneration seen when par-1^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Xenogenetic Interactions

Statement

Reference

Expression of lkb1^{dsRNA.Scer\UAS.cWa} enhances the rough eye phenotype seen when Hsap\APP^{695.T.Scer\UAS} and Hsap\MAPT^Scer\UAS.cWa are co-expressed under the control of Scer\GAL4^GMR.PF.

Expression of lkb1^{dsRNA.Scer\UAS.cWa} suppresses the rough eye phenotype seen when par-1^{Scer\UAS.T:Hsap\MYC} and Hsap\APP^{695.T.Scer\UAS} are co-expressed under the control of Scer\GAL4^GMR.PF.

(Wang et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Lkb1^RNAi.UAS.cWa

Lkb1^{dsRNA.Scer\UAS.cWa}

Lkb1^{dsRNA.UAS.cWa}

lkb1^{dsRNA.Scer\UAS.cWa}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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