FB2024_02 , released April 23, 2024
Gene: Dmel\Pgant35A
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General Information
Symbol
Dmel\Pgant35A
Species
D. melanogaster
Name
Polypeptide N-acetylgalactosaminyltransferase 35A
Annotation Symbol
CG7480
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001970
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
polypeptide N-acetylgalactosaminyltransferase (2.4.1.41)
Gene Summary
Polypeptide N-acetylgalactosaminyltransferase 35A (Pgant35A) encodes a member of the UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase family. It catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. The product of Pgant35A is an essential protein involved in epithelial tube polarity. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(2)35Aa, l(2)br12, br12, BG:DS01068.8 , dGalNAc-T1

Key Links
Genomic Location
Cytogenetic map
35A4-35A4
Sequence location
Recombination map
2-50
RefSeq locus
NT_033779 REGION:14359252..14361411
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables polypeptide N-acetylgalactosaminyltransferase activity
inferred from direct assay
(Schwientek et al., 2002, Ten Hagen and Tran, 2002)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables Notch binding
inferred from biological aspect of ancestor with PANTHER:PTN000912869
(GO Reference Genome Project, 2011-)
enables polypeptide N-acetylgalactosaminyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN004287905
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in oligosaccharide biosynthetic process
inferred from direct assay
(Schwientek et al., 2002, Ten Hagen and Tran, 2002)
involved_in open tracheal system development
inferred from mutant phenotype
(Tian and Ten Hagen, 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in protein O-linked glycosylation
inferred from biological aspect of ancestor with PANTHER:PTN004287905
(GO Reference Genome Project, 2011-)
involved_in regulation of Notch signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000912869
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in Golgi apparatus
inferred from biological aspect of ancestor with PANTHER:PTN000187024
(GO Reference Genome Project, 2011-)
located_in Golgi stack
non-traceable author statement
(Ten Hagen and Tran, 2002)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. (Q8MVS5)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
polypeptide N-acetylgalactosaminyltransferase activity
(1) L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP (2.4.1.41)
(2) L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O- [N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP (2.4.1.41)
Summaries
Gene Snapshot
Polypeptide N-acetylgalactosaminyltransferase 35A (Pgant35A) encodes a member of the UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase family. It catalyzes the transfer of a GalNAc sugar onto the hydroxyl groups of serine and threonine in secreted or membrane-bound proteins. The product of Pgant35A is an essential protein involved in epithelial tube polarity. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASES -
Polypeptide N-acetylgalactosaminyltransferase catalyze the transfer of N-Acetylgalactosamine (GalNAc) from UDP-GalNAc to serine and threonine acceptor sites and initiate mucin-type O-glycosylation. (Adapted from FBrf0151358 and FBrf0190815).
Protein Function (UniProtKB)
Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:11925450, PubMed:12829714). Displays the same enzyme activity toward MUC1, MUC4, and EA2 (PubMed:11925450, PubMed:12829714). Not involved in glycosylation of erythropoietin (EPO) (PubMed:11925450). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:11925450, PubMed:12829714). Protein modification by this enzyme might be important for cytokinesis and tube formation during embryogenesis (PubMed:16251381, PubMed:20807760). Together with Pgant3, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles (PubMed:25253852).
(UniProt, Q8MVS5)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pgant35A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8MVS5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pgant35A-RA
FBtr0080629
NM_143812
2160
632
Additional Transcript Data and Comments
Reported size (kB)

2.2 (northern blot)

(Schwientek et al., 2002)

2.3 (northern blot)

(Ten Hagen and Tran, 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Pgant35A-PA
FBpp0080202
71.8
632
9.04
Q8MVS5
NP_652069
AAF53391
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

632 (aa)

(Schwientek et al., 2002, Ten Hagen and Tran, 2002)
Comments
External Data
Domain

There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.

The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.

(UniProt, Q8MVS5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pgant35A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.40

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Tian and Ten Hagen, 2006)
embryonic stage 4 -- 6
organism | intense | ubiquitous

Comment: very slight anterior enrichment

(Tian and Ten Hagen, 2006)
embryonic stage 9 -- 11
foregut primordium
(Tian and Ten Hagen, 2006)
anterior midgut primordium
(Tian and Ten Hagen, 2006)
posterior midgut primordium
(Tian and Ten Hagen, 2006)
embryonic stage 9 -- 13
hindgut proper primordium
(Tian and Ten Hagen, 2006)
embryonic stage 12 -- 13
embryonic/larval midgut primordium | posterior
(Tian and Ten Hagen, 2006)
embryonic stage 12 -- 15
salivary gland body primordium
(Tian and Ten Hagen, 2006)
embryonic stage 14 -- 15
embryonic/larval hindgut
(Tian and Ten Hagen, 2006)
embryonic stage 16 -- 17
embryonic/larval salivary gland
(Tian and Ten Hagen, 2006)
embryonic/larval posterior spiracle
(Tian and Ten Hagen, 2006)
embryonic/larval tracheal dorsal trunk
(Tian and Ten Hagen, 2006)
third instar larval stage
wing disc | intense | ubiquitous
(Tian and Ten Hagen, 2006)
haltere disc | intense | ubiquitous
(Tian and Ten Hagen, 2006)
leg disc | ubiquitous
(Tian and Ten Hagen, 2006)
eye disc | ubiquitous
(Tian and Ten Hagen, 2006)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Schwientek et al., 2002)
adult stage | female
(Schwientek et al., 2002)
ovary
(Schwientek et al., 2002)
adult stage | male
testis
(Schwientek et al., 2002)
(Schwientek et al., 2002)
oogenesis
germline cell
(Schwientek et al., 2002)
follicle cell
(Schwientek et al., 2002)
pcr
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Ten Hagen and Tran, 2002)
embryonic stage & larval stage & adult stage
(Ten Hagen and Tran, 2002)
adult stage | male
(Ten Hagen and Tran, 2002)
adult stage | female
(Ten Hagen and Tran, 2002)
Additional Descriptive Data

Pgant35A transcripts are detected in males and females on northern blots. High levels are expressed in the ovary. Lower levels are observed in the testis and in the carcasses. Analysis of unfertilized eggs and early embryos reveals a strong maternal contribution. In situ hybridization during oogenesis reveals expression in germ cells and in follicle epithelia throughout oogenesis.

(Schwientek et al., 2002)

Pgant35A transcripts are detected in all stages from embryo to adult as tested by pcr and northern blot.

(Ten Hagen and Tran, 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pgant35A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pgant35A
Transgenic constructs containing regulatory region of Pgant35A
Aberrations (Deficiencies and Duplications) ( 156 )
Inferred from experimentation ( 156 )
Gene disrupted in
Df(2L)64j
(Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)A47
(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)
Df(2L)A215
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A217
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A246
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A263
(Ashburner et al., 1982)
Df(2L)A337
(Fossett et al., 1994)
Df(2L)A376
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A377
(Ashburner et al., 1982)
Df(2L)Adh-nBR100
(Fossett et al., 1994)
Df(2L)Adh-nBR101
(Fossett et al., 1994)
Df(2L)Adh-nBR103
(Fossett et al., 1994)
Df(2L)Adh-nBR117
(Fossett et al., 1994)
Df(2L)Adh-nBR120
(Fossett et al., 1994)
Df(2L)Adh-nBR125
(Fossett et al., 1994)
Df(2L)Adh-nBR130
(Fossett et al., 1994)
Df(2L)Adh-nBR131
(Fossett et al., 1994)
Df(2L)b80e3
(Flores and Engels, 1999, Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b81a1
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)b83d29a
(Roote et al., 1996, Davis et al., 1990)
Df(2L)b84a2
(Roote et al., 1996, Davis et al., 1990)
Df(2L)b84a4
(Roote et al., 1996)
Df(2L)b84h1
(Flores and Engels, 1999, Roote, 1996.1.30, Roote et al., 1996)
Df(2L)b88h49
(Roote et al., 1996)
Df(2L)el77
(Woodruff and Ashburner, 1979)
Df(2L)EP(2)2039-rv4
(Roote, 2000.6.13)
Df(2L)Exel6035
(Ryder, 2004.4.26)
Df(2L)fn1
(Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn5
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn7
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn12
(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn26
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn30
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn31
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn36
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)GT4
(Gubb et al., 1990)
Df(2L)GT5
(Gubb et al., 1990)
Df(2L)k08712-rv21
(Roote, 2009.11.24, Roote, 2000.6.13, Ashburner et al., 1999)
Df(2L)ppk1Aid
(Wegman et al., 2010)
Df(2L)TE35B-2
(Gubb et al., 1985)
Df(2L)TE35B-3
(Gubb et al., 1985)
Df(2L)TE35B-4
(Gubb et al., 1985)
Df(2L)TE35B-5
(Gubb et al., 1985)
Df(2L)TE35B-7
(Ashburner et al., 1999, Flores and Engels, 1999, Davis et al., 1997, Roote, 1996.1.30, Roote et al., 1996, Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-8
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-9
(Gubb et al., 1985)
Df(2L)TE35B-10
(Gubb et al., 1985)
Df(2L)TE35B-15
(Gubb et al., 1985)
Df(2L)TE35B-300
(Roote et al., 1996)
Df(2L)TE35BC-6
(Gubb et al., 1984)
Df(2L)TE35BC-23
(Gubb et al., 1984)
Df(2L)TE35BC-29
(Gubb et al., 1984)
Df(2L)TE35BC-31
(Gubb et al., 1984)
Df(2L)W
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
In(2L)75cLC158.1R
(Woodruff and Ashburner, 1979)
In(2L)75c
(Woodruff and Ashburner, 1979)
In(2LR)D20Lnoc4R
(Roote et al., 1996)
T(Y;2)GT2
(Gubb et al., 1990)
Tp(2;3)GT3
(Gubb et al., 1990)
Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209
(Roote et al., 1996)
Gene not disrupted in
Df(2L)A48
(Roote et al., 1996, Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A63
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A72
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A178
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A220
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A245
(Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982)
Df(2L)A260
(Davis et al., 1990, Ashburner et al., 1982)
Df(2L)A264
(Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)A266
(Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A267
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A379
(Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A400
(Flores and Engels, 1999, Roote et al., 1996, Fossett et al., 1994, Davis et al., 1990, Ashburner et al., 1982, Ashburner et al., 1982)
Df(2L)A445
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982)
Df(2L)Adh-nBR102
(Roote et al., 1996, Fossett et al., 1994)
Df(2L)Adh-nBR105
(Fossett et al., 1994)
Df(2L)Adh-nBR106
(Fossett et al., 1994)
Df(2L)Adh-nBR107
(Fossett et al., 1994)
Df(2L)Adh-nBR118
(Fossett et al., 1994)
Df(2L)Adh-nBR119
(Fossett et al., 1994)
Df(2L)Adh-nBR121
(Fossett et al., 1994)
Df(2L)Adh-nBR122
(Fossett et al., 1994)
Df(2L)Adh-nBR126
(Fossett et al., 1994)
Df(2L)Adh-nBR127
(Fossett et al., 1994)
Df(2L)Adh-nBR128
(Fossett et al., 1994)
Df(2L)Adh-nBR129
(Fossett et al., 1994)
Df(2L)ARR1
(Roote et al., 1996, Davis et al., 1990)
Df(2L)b75
(Gubb et al., 1990, Woodruff and Ashburner, 1979)
Df(2L)el14
(Roote et al., 1996, Davis et al., 1990)
Df(2L)el16
(Davis et al., 1990)
Df(2L)el28
(Davis et al., 1990)
Df(2L)el94
(Roote, 1996.1.11, Roote, 1996.8)
Df(2L)fn2
(Roote et al., 1996, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn3
(Davis et al., 1990, Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)
Df(2L)fn15
(Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)fn27
(Ashburner et al., 1982, Ashburner et al., 1982, O'Donnell et al., 1977)
Df(2L)n78l3
(Ashburner et al., 1982)
Df(2L)osp29
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)osp144
(Roote et al., 1996, Ashburner et al., 1982)
Df(2L)Scorv4
(Woodruff and Ashburner, 1979)
Df(2L)TE35B-1
(Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-6
(Davis et al., 1990, Gubb et al., 1985)
Df(2L)TE35B-11
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-12
(Roote et al., 1996, Gubb et al., 1985)
Df(2L)TE35B-54L
(Roote et al., 1996)
Df(2L)TE35BC-1
(Gubb et al., 1984)
Df(2L)TE35BC-3
(Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-4
(Roote et al., 1996, Gubb et al., 1984, Ashburner et al., 1982)
Df(2L)TE35BC-7
(Gubb et al., 1984)
Df(2L)TE35BC-8
(Davis et al., 1990, Gubb et al., 1984)
Df(2L)TE35BC-24
(Gubb et al., 1984)
Df(2L)TE35BC-28
(Gubb et al., 1984)
Df(2L)TE35BC-34
(Gubb et al., 1984)
Df(2L)TE35BC-35
(Gubb et al., 1984)
Dp(2;2)Cam12
(Roote et al., 1996)
In(2L)C158LScorv11R
(Ashburner and Harrington, 1984)
In(2L)C158LScorv17R
(Ashburner and Harrington, 1984)
In(2L)el9
(Davis et al., 1990)
In(2L)TE35B-13
(Roote, 1996.8, Gubb et al., 1985)
In(2LR)DTD128
(Davis et al., 1990)
In(2LR)el6
(Davis et al., 1990)
In(2LR)el6LA379R
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
In(2LR)noc4LScorv9R
(Ashburner and Harrington, 1984)
In(2LR)TE35B-6LScorv9R
(Ashburner and Harrington, 1984)
T(2;3)dpps19
(Davis et al., 1990)
T(2;3)el24
(Davis et al., 1990)
T(2;3)GT8
(Davis et al., 1990)
T(2;3)GT10
(Davis et al., 1990)
T(2;3)Scorv7
(Woodruff and Ashburner, 1979)
T(2;4)GT6
(Roote, 1999.6.8)
T(Y;2)a15
(Davis et al., 1990)
T(Y;2)A80DR15P
(Ashburner et al., 1982, Woodruff and Ashburner, 1979)
T(Y;2)A80
(Davis et al., 1990)
T(Y;2)el4
(Davis et al., 1990)
T(Y;2)GT2
(Roote et al., 1996, Davis et al., 1990)
T(Y;2)J165DP58P
(Woodruff and Ashburner, 1979)
T(Y;2)R15DJ165P
(Woodruff and Ashburner, 1979)
Tp(2;2)A446
(Roote et al., 1996, Fossett et al., 1994, Ashburner et al., 1982, Ashburner et al., 1982)
Tp(2;3)GT3
(Roote et al., 1996, Davis et al., 1990)
Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13
(Ashburner and Harrington, 1984)
Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90
(Roote et al., 1996)
Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13
(Ashburner and Harrington, 1984)
Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80
(Roote, 1996.1.11, Roote, 1996.8)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996, Ashburner et al., 1982)
Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80
(Roote, 1996.1.11, Roote, 1996.8, Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15
(Davis et al., 1990)
Gene duplicated in
Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74
(Roote et al., 1996)
Gene not duplicated in
Dp(2;2)TE35B-54L
(Roote et al., 1996)
Dp(2;3)osp3
(Roote et al., 1996)
In(2L)C163.41LC158R
(Roote et al., 1996)
In(2LR)TE35B-226LDTD128R
(Roote et al., 1996)
Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18
(Roote et al., 1996)
Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80
(Roote et al., 1996)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4how-24B
lethal, with Scer\GAL4αTub84B.PL
lethal (with Df(2L)b84h1)
lethal | embryonic stage (with Pgant35A1)
lethal | embryonic stage (with Pgant35A3)
lethal | embryonic stage (with Pgant35A4)
lethal | embryonic stage | maternal effect
lethal | embryonic stage | maternal effect (with Pgant35A1)
lethal | embryonic stage | maternal effect (with Pgant35A3)
lethal | embryonic stage | maternal effect (with Pgant35A4)
lethal | larval stage (with Pgant35A1)
lethal | larval stage (with Pgant35A3)
lethal | larval stage (with Pgant35A4)
lethal | larval stage | maternal effect
lethal | larval stage | maternal effect (with Pgant35A3)
lethal | larval stage | maternal effect (with Pgant35A4)
lethal | pupal stage (with Pgant35A1)
lethal | pupal stage (with Pgant35A3)
lethal | pupal stage (with Pgant35A4)
lethal | recessive
lethal - all die during embryonic stage | maternal effect
partially lethal - majority die, with Scer\GAL4btl.PS
partially lethal - majority die, with Scer\GAL4c179
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
some die during embryonic stage | maternal effect
wild-type
Phenotype manifest in
Allele
embryonic/larval tracheal dorsal trunk (with Pgant35A1)
embryonic/larval tracheal dorsal trunk (with Pgant35A3)
embryonic/larval tracheal dorsal trunk (with Pgant35A4)
embryonic/larval tracheal system (with Pgant35A1)
embryonic/larval tracheal system (with Pgant35A3)
embryonic/larval tracheal system (with Pgant35A4)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (21)
Hsap\GALNT11
13 of 14
Yes
Yes
1  
Hsap\GALNTL5
6 of 14
No
Yes
Hsap\GALNT1
3 of 14
No
No
Hsap\GALNT2
3 of 14
No
No
3  
Hsap\GALNT3
3 of 14
No
No
Hsap\GALNT4
3 of 14
No
No
Hsap\GALNT5
3 of 14
No
No
Hsap\GALNT7
3 of 14
No
No
Hsap\GALNT12
3 of 14
No
No
Hsap\GALNT13
3 of 14
No
No
Hsap\GALNT14
3 of 14
No
No
Hsap\GALNT15
3 of 14
No
No
Hsap\GALNT16
3 of 14
No
No
Hsap\GALNT6
2 of 14
No
No
Hsap\GALNT8
2 of 14
No
No
Hsap\GALNT9
2 of 14
No
No
Hsap\GALNT10
2 of 14
No
No
Hsap\GALNT17
2 of 14
No
No
Hsap\GALNT18
2 of 14
No
No
Hsap\GALNTL6
2 of 14
No
No
Hsap\POC1B-GALNT4
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Galnt11
13 of 14
Yes
Yes
Rnor\Galntl5
6 of 14
No
Yes
Rnor\Galnt1
3 of 14
No
No
Rnor\Galnt2
3 of 14
No
No
Rnor\Galnt3
3 of 14
No
No
Rnor\Galnt5
3 of 14
No
No
Rnor\Galnt7
3 of 14
No
No
Rnor\Galnt13
3 of 14
No
No
Rnor\Galnt14
3 of 14
No
No
Rnor\Galnt16
3 of 14
No
No
Rnor\Galnt6
2 of 14
No
No
Rnor\Galnt9
2 of 14
No
No
Rnor\Galnt10
2 of 14
No
No
Rnor\Galnt12
2 of 14
No
No
Rnor\Galnt18
2 of 14
No
No
Rnor\Galnt4
1 of 14
No
Yes
Rnor\Galnt8
1 of 14
No
Yes
Rnor\Galnt15
1 of 14
No
No
Rnor\Galnt17
1 of 14
No
Yes
Rnor\Galntl6
1 of 14
No
No
Mus musculus (laboratory mouse) (19)
Mmus\Galnt11
13 of 14
Yes
Yes
Mmus\Galntl5
6 of 14
No
Yes
Mmus\Galnt1
3 of 14
No
No
Mmus\Galnt2
3 of 14
No
No
Mmus\Galnt3
3 of 14
No
No
Mmus\Galnt4
3 of 14
No
No
Mmus\Galnt6
3 of 14
No
No
Mmus\Galnt7
3 of 14
No
No
Mmus\Galnt12
3 of 14
No
No
Mmus\Galnt13
3 of 14
No
No
Mmus\Galnt14
3 of 14
No
No
Mmus\Galnt15
3 of 14
No
No
Mmus\Galnt16
3 of 14
No
No
Mmus\Galnt5
2 of 14
No
No
Mmus\Galnt9
2 of 14
No
No
Mmus\Galnt10
2 of 14
No
No
Mmus\Galnt17
2 of 14
No
No
Mmus\Galnt18
2 of 14
No
No
Mmus\Galntl6
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (23)
Xtro\galnt11
11 of 13
Yes
Yes
Xtro\fam177b
9 of 13
No
Yes
Xtro\galnt4
2 of 13
No
No
Xtro\galnt7
2 of 13
No
No
Xtro\galnt13
2 of 13
No
No
Xtro\pde1a
2 of 13
No
No
Xtro\anxa10
1 of 13
No
No
Xtro\dapk2
1 of 13
No
Yes
Xtro\ddr2
1 of 13
No
No
Xtro\galnt1
1 of 13
No
No
Xtro\galnt2
1 of 13
No
No
Xtro\galnt3
1 of 13
No
No
Xtro\galnt5
1 of 13
No
No
Xtro\galnt6.1
1 of 13
No
Yes
Xtro\galnt6.2
1 of 13
No
No
Xtro\galnt6.3
1 of 13
No
Yes
Xtro\galnt9
1 of 13
No
No
Xtro\galnt12
1 of 13
No
No
Xtro\galnt14
1 of 13
No
No
Xtro\galnt15
1 of 13
No
No
Xtro\galnt16
1 of 13
No
No
Xtro\galnt18
1 of 13
No
No
Xtro\znf414
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\galnt11
14 of 14
Yes
Yes
Drer\galnt1
3 of 14
No
No
Drer\galnt6
3 of 14
No
No
Drer\galnt12
3 of 14
No
No
Drer\galnt14
3 of 14
No
No
Drer\galnt16
3 of 14
No
No
Drer\galnt2
2 of 14
No
No
Drer\galnt3
2 of 14
No
No
Drer\galnt7
2 of 14
No
No
Drer\galnt8a.2
2 of 14
No
No
Drer\galnt8b.1
2 of 14
No
No
Drer\galnt8b.2
2 of 14
No
No
Drer\galnt9
2 of 14
No
No
Drer\galnt13
2 of 14
No
No
Drer\galnt17
2 of 14
No
No
Drer\galnt18b
2 of 14
No
No
Drer\galntl6
2 of 14
No
No
Drer\poc1bl
2 of 14
No
No
Drer\galnt5
1 of 14
No
No
Drer\galnt8a.1
1 of 14
No
No
Drer\galnt18a
1 of 14
No
No
Drer\LOC103910015
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\gly-11
8 of 14
Yes
Yes
Cele\gly-8
5 of 14
No
Yes
Cele\gly-3
3 of 14
No
No
Cele\gly-7
3 of 14
No
No
Cele\gly-4
2 of 14
No
No
Cele\gly-5
2 of 14
No
No
Cele\gly-6
2 of 14
No
No
Cele\gly-9
2 of 14
No
No
Cele\gly-10
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP004429
12 of 12
Yes
Yes
Agam\AgaP_AGAP000656
3 of 12
No
No
Agam\AgaP_AGAP006881
3 of 12
No
No
Agam\AgaP_AGAP006925
3 of 12
No
No
Agam\AgaP_AGAP008229
3 of 12
No
No
Agam\AgaP_AGAP008613
3 of 12
No
No
Agam\AgaP_AGAP010078
3 of 12
No
No
Agam\AgaP_AGAP010367
3 of 12
No
No
Agam\AgaP_AGAP011984
3 of 12
No
No
Agam\AgaP_AGAP012414
3 of 12
No
No
Agam\AgaP_AGAP004375
2 of 12
No
No
Agam\AgaP_AGAP012253
2 of 12
No
No
Agam\AgaP_AGAP012254
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Pgant35A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (13)
CG31776
5 of 13
Pgant2
5 of 13
Pgant4
5 of 13
Pgant5
5 of 13
Pgant6
5 of 13
Pgant7
5 of 13
Pgant8
5 of 13
Pgant9
5 of 13
CG7304
4 of 13
CG7579
4 of 13
CG10000
4 of 13
Pgant1
4 of 13
Pgant3
4 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GALNT11; polypeptide N-acetylgalactosaminyltransferase 11
    13 of 14
    615130
         
        GALNTL5; polypeptide N-acetylgalactosaminyltransferase like 5
        6 of 14
        615133
            GALNT1; polypeptide N-acetylgalactosaminyltransferase 1
            3 of 14
            602273
                GALNT2; polypeptide N-acetylgalactosaminyltransferase 2
                3 of 14
                602274
                   
                  GALNT3; polypeptide N-acetylgalactosaminyltransferase 3
                  3 of 14
                  601756
                  GALNT4; polypeptide N-acetylgalactosaminyltransferase 4
                  3 of 14
                  603565
                      GALNT5; polypeptide N-acetylgalactosaminyltransferase 5
                      3 of 14
                      615129
                          GALNT7; polypeptide N-acetylgalactosaminyltransferase 7
                          3 of 14
                          605005
                              GALNT12; polypeptide N-acetylgalactosaminyltransferase 12
                              3 of 14
                              610290
                                GALNT13; polypeptide N-acetylgalactosaminyltransferase 13
                                3 of 14
                                608369
                                    GALNT14; polypeptide N-acetylgalactosaminyltransferase 14
                                    3 of 14
                                    608225
                                        GALNT15; polypeptide N-acetylgalactosaminyltransferase 15
                                        3 of 14
                                        615131
                                            GALNT16; polypeptide N-acetylgalactosaminyltransferase 16
                                            3 of 14
                                            615132
                                                Functional Complementation Data
                                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                Interactions
                                                Summary of Physical Interactions
                                                esyN Network Diagram
                                                Show neighbor-neighbor interactions:
                                                Show/hide secondary interactors 
                                                (data from AllianceMine provided by esyN)
                                                Select Layout:
                                                Legend:
                                                Protein
                                                RNA
                                                Selected Interactor(s)
                                                Interactions Browser
                                                View in Interactions Browser
                                                Please see the Physical Interaction reports below for full details
                                                MIST Molecular Interaction Search Tool
                                                View in MIST tool (external link)
                                                Please see the Physical Interaction reports below for full details
                                                protein-protein
                                                Physical Interaction
                                                Assay
                                                References
                                                Pgant35A - Ten-m
                                                enzymatic study, autoradiography
                                                (Zhang et al., 2008)
                                                RNA-protein
                                                Physical Interaction
                                                Assay
                                                References
                                                Pgant35A - Mi-2
                                                iclip, partial RNA sequence identification, electrophoretic mobility shift assay, fluorescence technology
                                                (Ullah et al., 2022)
                                                Summary of Genetic Interactions
                                                esyN Network Diagram
                                                Starting gene(s)
                                                Interaction type
                                                Interacting gene(s)
                                                Reference
                                                Starting gene(s)
                                                Interaction type
                                                Interacting gene(s)
                                                Reference
                                                External Data
                                                Linkouts
                                                DroID - A comprehensive database of gene and protein interactions.
                                                Pathways
                                                Signaling Pathways (FlyBase)
                                                Metabolic Pathways
                                                FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                                KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                External Data
                                                Linkouts
                                                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                Genomic Location and Detailed Mapping Data
                                                Chromosome (arm)
                                                2L
                                                Recombination map
                                                2-50
                                                Cytogenetic map
                                                35A4-35A4
                                                Sequence location
                                                FlyBase Computed Cytological Location
                                                Cytogenetic map
                                                Evidence for location
                                                35A4-35A4
                                                Limits computationally determined from genome sequence between P{lacW}l(2)34Fak00811&P{PZ}wb09437 and P{EP}elBEP2039&P{PZ}osprJ571
                                                Experimentally Determined Cytological Location
                                                Cytogenetic map
                                                Notes
                                                References
                                                Experimentally Determined Recombination Data
                                                Location

                                                2-50

                                                (FlyBase, 2016)

                                                2-46.2

                                                (Comeron et al., 2012)
                                                Left of (cM)
                                                (Roote, 1996.1.30)
                                                Right of (cM)
                                                (Woodruff and Ashburner, 1979)
                                                Notes

                                                Excisions of Rab14k08712 show that the gene order is ms(2)34Fe, l(2)34Fd, Rab14, Pgant35A.

                                                (Ashburner et al., 1999.10.12)
                                                Stocks and Reagents
                                                Stocks (11)
                                                Genomic Clones (19)
                                                cDNA Clones (2)
                                                 

                                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                cDNA clones, fully sequenced
                                                BDGP DGC clones
                                                Other clones
                                                Drosophila Genomics Resource Center cDNA clones

                                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                cDNA Clones, End Sequenced (ESTs)
                                                BDGP DGC clones
                                                  Other clones
                                                    RNAi and Array Information
                                                    Linkouts
                                                    DRSC - Results frm RNAi screens
                                                    Antibody Information
                                                    Laboratory Generated Antibodies
                                                     
                                                    Commercially Available Antibodies
                                                     
                                                    Cell Line Information
                                                    Publicly Available Cell Lines
                                                     
                                                      Other Stable Cell Lines
                                                       
                                                        Other Comments

                                                        The lethal phenotype of Pgant35A-/Pgant35A- and Df(2L)TE35B-7/Df(2L)b84h1 (with both Pgant35A and spel1 deleted) can be rescued by a fragment of genomic DNA that includes Pgant35A but not spel1.

                                                        (Roote, 1996.1.30)
                                                        Relationship to Other Genes
                                                        Source for database merge of

                                                        Source for merge of: l(2)35Aa CG7480

                                                        (Misra, 2000.4.12)
                                                        Additional comments

                                                        The Pgant35A gene may have been derived from the CG10000 gene by retroposition.

                                                        (Pan and Zhang, 2009)

                                                        FlyBase curator comment: "l(2)35Aa" (FBgn0001970, Pgant35A, CG7480) is also referred to in FBrf0151358 as "dGalNAc-T1", but "l(2)35Aa" is not the same gene as the gene with the valid symbol "GalNAc-T1" in FlyBase, which is FBgn0034025, CG8182 described in FBrf0130686 (accession number AF218236).

                                                        (Schwientek et al., 2002)
                                                        Nomenclature History
                                                        Source for database identify of

                                                        Source for identity of: Pgant35A l(2)35Aa

                                                        (Ten Hagen and Tran, 2002)
                                                        Nomenclature comments
                                                        Etymology
                                                        Synonyms and Secondary IDs (17)
                                                        Reported As
                                                        Symbol Synonym
                                                        A3
                                                        (O'Donnell et al., 1977)
                                                        BG:DS01068.8
                                                        (Ashburner et al., 1999, Ashburner et al., 1999.10.12)
                                                        CG7480
                                                        (National Institute of Genetics Fly Stocks, 2022-, Yamamoto-Hino et al., 2015, Dani et al., 2012, Tran et al., 2012, Bennett et al., 2010, Pan and Zhang, 2009, Perkins et al., 2009, Tian and Ten Hagen, 2006, Ten Hagen et al., 2003, Misra, 2001.4.26)
                                                        GalNAc-T
                                                        (Flores and Engels, 1999)
                                                        Pgant35A
                                                        (Rust et al., 2020, Zhang and Ten Hagen, 2019, Aradska et al., 2015, dos Santos, 2014, Czech et al., 2008)
                                                        Pgant35a
                                                        (Ullah et al., 2022)
                                                        br12
                                                        (Gubb et al., 1985, Ashburner and Harrington, 1984)
                                                        dGalNAc-T1
                                                        (Wang et al., 2018, Schwientek et al., 2002)
                                                        l(2)35Aa
                                                        (Bennett et al., 2010, Roote, 2009.11.24, Bolshakov et al., 2002, Schwientek et al., 2002, Wilson, 2002, Roote, 2000.6.13, Ashburner et al., 1999, Ashburner et al., 1999, Davis et al., 1997, Roote, 1996.1.11, Roote, 1996.1.30, Roote et al., 1996, Spradling et al., 1995, Davis et al., 1990, Gubb et al., 1990, Gubb et al., 1988)
                                                        l(2)br12
                                                        (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner et al., 1982, Ashburner et al., 1982, Woodruff and Ashburner, 1979)
                                                        l35Aa
                                                        (Fossett et al., 1994)
                                                        pgant35
                                                        (Walski et al., 2017, Ten Hagen et al., 2003)
                                                        pgant35A
                                                        (Li et al., 2020, Nishihara, 2020, Wang et al., 2018, Yamamoto-Hino et al., 2015, Dani et al., 2014, Tran et al., 2012, Bennett et al., 2010, Zhang and Ten Hagen, 2010, Zhang et al., 2010, Zhang et al., 2008, Tian and Ten Hagen, 2007, Yi et al., 2007, Tian and Hagen, 2006, Tian and Ten Hagen, 2006, Ten Hagen and Tran, 2002)
                                                        ppGalNAcT35A
                                                        (Itoh and Nishihara, 2021)
                                                        Name Synonyms
                                                        Polypeptide N-acetylgalactosaminyltransferase 35A
                                                        (Ten Hagen and Tran, 2002)
                                                        lethal 12 in the black-reduced region
                                                        (Woodruff and Ashburner, 1979)
                                                        lethal group A3
                                                        (O'Donnell et al., 1977)
                                                        Secondary FlyBase IDs
                                                        • FBgn0027860
                                                        • FBgn0032545
                                                        Datasets (0)
                                                        Study focus (0)
                                                        Experimental Role
                                                        Project
                                                        Project Type
                                                        Title
                                                        Study result (0)
                                                        Result
                                                        Result Type
                                                        Title
                                                        External Crossreferences and Linkouts ( 50 )
                                                        Sequence Crossreferences
                                                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                        Other crossreferences
                                                        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                        FlyMine - An integrated database for Drosophila genomics
                                                        InterPro - A database of protein families, domains and functional sites
                                                        KEGG Genes - Molecular building blocks of life in the genomic space.
                                                        MARRVEL_MODEL - MARRVEL (model organism gene)
                                                        Linkouts
                                                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                        DroID - A comprehensive database of gene and protein interactions.
                                                        DRSC - Results frm RNAi screens
                                                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                        Flygut - An atlas of the Drosophila adult midgut
                                                        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                        References (86)