FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(2L)b84h1
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General Information
Symbol
Df(2L)b84h1
Species
D. melanogaster
Name
Deficiency (2L) black
FlyBase ID
FBab0001738
Feature type
chromosomal_deletion
Computed Breakpoints include

34D4;35A4

Features within 34D4--35A4
Sequence coordinates
2L:13,810,408..13,816,406 [+] (Df(2L)b84h1:bk1)
(Simon et al., 1991)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Roote et al., 1996)
Breakpoints

34D3;35A4

(Roote et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

l(2)34Db << bk1 << Sos << Pgant35A << bk2 << elB

Genetic mapping information
Comments

Breakpoint 1 was linked to an XbaI-BamHI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Simon et al., 1991)
Comments on Cytology

Left limit of break 1 from non-inclusion of l(2)34Db (FBrf0057637) Right limit of break 1 from inclusion of Sos (FBrf0057637) Limits of break 2 from polytene analysis (FBrf0091422)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Pgant35A
(Flores and Engels, 1999, Roote, 1996.1.30, Roote et al., 1996)
Sos
(Roote et al., 1996, Bonfini et al., 1992)
spel1
(Kappeler et al., 2008)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
kuz
(Bonfini et al., 1992)
l(2)34Db
(Bonfini et al., 1992)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(2L)b84h1 in combination with Df(2L)k08712-rv21 do not exhibit a change in the frequency of single strand annealing.

    (Kappeler et al., 2008)

    Df(2L)TE35B-7/Df(2L)b84h1 flies carrying Pgant35A+tGal show normal sensitivity to methyl methanesulfonate or γ rays. Df(2L)TE35B-7/Df(2L)b84h1 flies carrying Pgant35A+tGal show significantly greater microsatellite instability compared to control flies. Df(2L)TE35B-7/Df(2L)b84h1 flies carrying Pgant35A+tGal show a decrease in the stability of the dinucleotide repeat present in the wA87.2 allele when it is copied into the site of a double-strand break during gene conversion.

    (Flores and Engels, 1999)
    NOT in combination with other aberrations

    Flies carrying both Df(2L)b84h1 and Df(2L)TE35B-7 are semi-sterile.

    (Williams et al., 2011)

    The lethal phenotype of Pgant35A-/Pgant35A- and Df(2L)TE35B-7/Df(2L)b84h1 (with both Pgant35A and spel1 deleted) can be rescued by a fragment of genomic DNA that includes Pgant35A but not spel1.

    (Roote, 1996.1.30)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Uncovers spel1.

    (Roote, 1996.1.30)
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Df(2L)b84h1
    (Bennett et al., 2010, Kappeler et al., 2008)
    Df(2L)b84hl
    (Ashburner et al., 1999)
    Name Synonyms
    Deficiency (2L) black
    Secondary FlyBase IDs
      References (13)