taras132 mutants show a substantial reduction in daily sleep in both males and females. Waking activity is slightly increased in both females and males compared with controls, but male heterozygotes also exhibit an increase in activity compared with controls. The duration of sleep bouts is similar to controls, but number of bouts is reduced. A significant reduction in sleep is also seen in male heterozygotes. Sleep latency (the time between lights off to the first sleep) is increased in females, but not in males.
taras132/tara1 mutant males and females show a reduction in daily sleep that is more severe than that seen in taras132 homozygotes. A significant reduction in sleep is also seen in male and female heterozygotes and waking activity is significantly increased in tara1/+ males.
Sleep bout duration is reduced in both males and female taras132/tara1 mutant flies. The number of sleep bouts is reduced in female flies, although a reduction in the number of sleep bouts is also seen in female heterozygotes. No reduction is sleep bout number is seen in male flies. Sleep latency (the time between lights off to the first sleep) is increased in both males and females.
taras132/tara1 mutant flies exhibit defects in locomotor rhythm in constant darkness.
taras132/tara1 mutant flies show severely reduced sleep compared to controls when assayed in either constant light or constant dark.
taras132/tarae01264 mutant males and females show a reduction in daily sleep that is more severe than that seen in taras132 homozygotes. A significant reduction in sleep is also seen in male and female heterozygotes and waking activity is significantly increased in tarae01264/+ males.
Sleep bout duration is reduced in both males and female taras132/tarae01264 mutant flies. The number of sleep bouts is reduced female flies, but not male flies. Sleep latency (the time between lights off to the first sleep) is increased in males but not females.
taras132/tarae01264 mutant flies exhibit weak defects in locomotor rhythm in constant darkness.
taras132/tarae01264 mutant flies show severely reduced sleep compared to controls when assayed in either constant light or constant dark.
taras132 has abnormal sleep | recessive phenotype, enhanceable by CycA[+]/CycAEY11746
taras132/tarae01264 has abnormal sleep phenotype, suppressible | partially by Cdk1[+]/Cdk1GT-000294
taras132/tarae01264 has abnormal sleep phenotype, suppressible | partially by Cdk1[+]/Cdk1c03495
One copy of CycAEY11746 enhances the sleep defects seen in taras132 mutant flies.
One copy of Cdk1GT-000294 substantially suppresses the sleep defects seen in taras132/tarae01264 mutant flies.
One copy of Cdk1c03495 substantially suppresses the sleep defects seen in taras132/tarae01264 mutant flies.
taras132/tarae01264 is rescued by taraβ.Ubi-p63E
taras132 is partially rescued by Scer\GAL4elav.Switch.PO, taras132
Scer\GAL4elav.Switch.PO, taras132 partially rescues taras132
Expression of taraβ.Ubi-p63E almost completely rescues the sleep defects seen in taras132/tarae01264 mutant females and males.
Adult-specific expression of tara (using the Scer\UAS site in taras132 under the control of RU486-dependent Scer\GAL4elav.Switch.PO) partially rescues the taras132 sleep phenotypes.
Excision of the P-element insertion restores normal sleep in taras132 mutant flies.