FB2024_03 , released June 25, 2024
Allele: Dmel\tarae01264
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General Information
Symbol
Dmel\tarae01264
Species
D. melanogaster
Name
FlyBase ID
FBal0177523
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Allele components
Component
Use(s)
Inserted element
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

taras132/tarae01264 mutant males and females show a reduction in daily sleep that is more severe than that seen in taras132 homozygotes. A significant reduction in sleep is also seen in male and female heterozygotes and waking activity is significantly increased in tarae01264/+ males.

Sleep bout duration is reduced in both males and female taras132/tarae01264 mutant flies. The number of sleep bouts is reduced female flies, but not male flies. Sleep latency (the time between lights off to the first sleep) is increased in males but not females.

taras132/tarae01264 mutant flies exhibit weak defects in locomotor rhythm in constant darkness.

taras132/tarae01264 mutant flies show severely reduced sleep compared to controls when assayed in either constant light or constant dark.

tarad40/tarae01264 mutants exhibit reduced sleep compared with controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

taras132/tarae01264 has abnormal sleep phenotype, suppressible | partially by Cdk1[+]/Cdk1c03495

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

One copy of Cdk1GT-000294 substantially suppresses the sleep defects seen in taras132/tarae01264 mutant flies.

One copy of Cdk1c03495 substantially suppresses the sleep defects seen in taras132/tarae01264 mutant flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of taraβ.Ubi-p63E almost completely rescues the sleep defects seen in taras132/tarae01264 mutant females and males.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)