FB2024_03 , released June 25, 2024
Allele: Dmel\MarfninaE.GD11094
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General Information
Symbol
Dmel\MarfninaE.GD11094
Species
D. melanogaster
Name
FlyBase ID
FBal0302643
Feature type
allele
Associated gene
Dmel\Marf
Associated Insertion(s)
Carried in Construct
P{ninaE-Marf-GD11094}
Also Known As
Rh-Marf RNAi
Key Links
Transgenic product class
RNAi_reagent
(Liu et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Liu et al., 2015)
Mutagen
in vitro construct
(Liu et al., 2015)
Progenitor genotype
Carried in construct
P{ninaE-Marf-GD11094}
Cytology
Description

A ninaE promoter drives expression of dsRNA-GD11094.

(Liu et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
ninaE
Encoded product / tool
dsRNA-GD11094
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of MarfninaE.GD11094 in photoreceptors induces formation of lipid droplets in the neighboring glial cells.

      (Liu et al., 2017)

      Expression of MarfninaE.GD11094 leads to lipid droplet accumulation in glia.

      (Liu et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      NOT Enhanced by
      Suppressed by
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing MarfninaE.GD11094 is ameliorated by combination with a single copy of any of the following: PdhaA, kdnA or GLazMI02243-TG4.0.

      (Liu et al., 2017)

      Neuronal expression of bskGD10555 under the control of Scer\GAL4elav.PU significantly reduces lipid droplet accumulation.

      Glia expression of bskGD10555 under the control of Scer\GAL454C does not affect lipid droplet accumulation in MarfninaE.GD11094 flies.

      (Liu et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference

      The amelioration of lipid droplet accumulation in glial cells in the retina of adult flies expressing MarfninaE.GD11094 observed upon combination with a single copy of GLazMI02243-TG4.0 is negated, to a varying extent (and the number of droplets significantly increased again), by Scer\GAL4GLaz-MI02243-TG4.0-driven (a driver inherent to the GLazMI02243-TG4.0 allele) expression of any of the following: Hsap\APOE2.C112.C158.UAS, Hsap\APOE3.C112.R158.UAS or Hsap\APOE4.R112.R158.UAS.

      (Liu et al., 2017)

      Neuronal expression of Hsap\SOD1Scer\UAS.cPa under the control of Scer\GAL4elav.PU significantly reduces lipid droplet accumulation in MarfninaE.GD11094 flies.

      (Liu et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      MarfninaE.GD11094
      Name Synonyms
      Secondary FlyBase IDs
        References (3)