Expression of a human APOE variant 2 (Cys112, Cys158) reported to protect against Alzheimer's disease (AD) and to a lesser extent also that of variant 3 (Cys112, Arg158) rescues the glial lipid droplet accumulation observed in ND42 or Marf knockdown flies that lack Glaz, while the variant 4 (Arg112, Arg158) associated with higher risk of developing AD does not improve the phenotype.
Expression of Hsap\APOE4.R112.R158.UAS under the control of Scer\GAL454C leads to accumulation of lipid droplets in glial cells in adult retina.
Hsap\APOE4.R112.R158.UAS, MarfninaE.GD11094, Scer\GAL4GLaz-MI02243-TG4.0 has abnormal neuroanatomy | adult stage phenotype, suppressible by Zzzz\aptamerCS6253.UAS.SS.Tag:HA, Scer\GAL4GLaz-MI02243-TG4.0
Hsap\APOE4.R112.R158.UAS, MarfninaE.GD11094, Scer\GAL4GLaz-MI02243-TG4.0 has rhabdomere | adult stage phenotype, suppressible by Zzzz\aptamerCS6253.UAS.SS.Tag:HA, Scer\GAL4GLaz-MI02243-TG4.0
Hsap\APOE4.R112.R158.UAS, MarfninaE.GD11094, Scer\GAL4GLaz-MI02243-TG4.0 has retina | adult stage phenotype, suppressible by Zzzz\aptamerCS6253.UAS.SS.Tag:HA, Scer\GAL4GLaz-MI02243-TG4.0
Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS is an enhancer of adult optic lobe glial cell | cell non-autonomous phenotype of GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220
Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS is an enhancer of lipid droplet | adult stage | cell non-autonomous phenotype of GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220
Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS is an enhancer of adult optic lobe glial cell | cell non-autonomous phenotype of GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094
Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS is an enhancer of lipid droplet | adult stage | cell non-autonomous phenotype of GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094
Hsap\APOE4.R112.R158.UAS, MarfninaE.GD11094, Scer\GAL4GLaz-MI02243-TG4.0 has retina | adult stage phenotype
The amelioration of lipid droplet accumulation in glial cells in the retina of adult flies expressing either ND-42ninaE.GD6220 or MarfninaE.GD11094 observed upon combination with a single copy of GLazMI02243-TG4.0 is negated (and the number of droplets significantly increased again), by Scer\GAL4GLaz-MI02243-TG4.0-driven (a driver inherent to the GLazMI02243-TG4.0 allele) expression of Hsap\APOE4.R112.R158.UAS.