FB2024_03 , released June 25, 2024
Allele: Dmel\GLazMI02243-TG4.0
Open Close
General Information
Symbol
Dmel\GLazMI02243-TG4.0
Species
D. melanogaster
Name
FlyBase ID
FBal0336593
Feature type
allele
Associated gene
Dmel\GLaz
Associated Insertion(s)
Mi{Trojan-GAL4.0}GLazMI02243-TG4.0
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Liu et al., 2017)
Progenitor genotype
Mi{MIC}GLazMI02243
(Liu et al., 2017)
Associated Insertion(s)
Mi{Trojan-GAL4.0}GLazMI02243-TG4.0
Cytology
Description

phiC31-mediated recombination (RMCE) has been used to replace Mi{MIC}GLazMI02243 with a "Trojan" exon containing a splice acceptor (SA), linker, T2A sequence and a GAL4 sequence followed by a poly(A) tail. This results in the production of a truncated GLaz protein (mutant) and Scer\GAL4 under the control of the endogenous Glaz regulatory elements ("GlazT2A-GAL4 gene trap").

(Liu et al., 2017)
Allele components
Component
Use(s)
Inserted element
Mi{Trojan-GAL4.0}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE2.C112.C158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE2.C112.C158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE3.C112.R158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE3.C112.R158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, ND-42ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Scer\GAL4GLaz-MI02243-TG4.0/Hsap\APOE4.R112.R158.UAS

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE2.C112.C158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE2.C112.C158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE3.C112.R158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)

      GLaz[+]/GLazMI02243-TG4.0, MarfninaE.GD11094 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE3.C112.R158.UAS/Scer\GAL4GLaz-MI02243-TG4.0

      (Liu et al., 2017)
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing either ND-42ninaE.GD6220 or MarfninaE.GD11094 is ameliorated by combination with a single copy of GLazMI02243-TG4.0.

      (Liu et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference

      The amelioration of lipid droplet accumulation in glial cells in the retina of adult flies expressing either ND-42ninaE.GD6220 or MarfninaE.GD11094 observed upon combination with a single copy of GLazMI02243-TG4.0 is negated, to a varying extent (and the number of droplets significantly increased again), by Scer\GAL4GLaz-MI02243-TG4.0-driven (a driver inherent to the GLazMI02243-TG4.0 allele) expression of any of the following: Hsap\APOE2.C112.C158.UAS, Hsap\APOE3.C112.R158.UAS or Hsap\APOE4.R112.R158.UAS.

      (Liu et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      GLazMI02243-TG4.0
      GlazT2A-GAL4
      (Liu et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)