FlyBase Allele Report: Dmel\bocks[Δ66]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\bocks^Δ66

General Information

Symbol

Dmel\bocks^Δ66

Species

D. melanogaster

Name

FlyBase ID

FBal0301062

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Barton et al., 2014)

Mutagen

Delta2-3 transposase

(Barton et al., 2014)

Progenitor genotype

P{PTT-GB}bocks^CB03586

(Barton et al., 2014)

Caused by aberration

Df(3R)bocks^Δ66

Cytology

Description

Imprecise excision of the progenitor P{PTT-GB}bocks^CB03586 insertion, resulting in a deletion that extends upstream from the original insertion site at +11 in bocks (this results in a lack of bocks protein expression in the mutant). The deletion removes the first promoter of the upstream CG8312 gene and only 225bp of sequence remain upstream of the second promoter. CG8312 RNA levels are reduced in mutant larvae.

(Barton et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

3R:9,590,985..9,591,701 [-]

Comment:

A 717 bp deletion from 3R:9590985 to 3R:9591701 resulting from the imprecise excision of P{PTT-GB}bocks^CB03586.

(Barton and Geyer, 2015.5.11)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile (with bocks^Δ10)

(Barton et al., 2014)

viable (with bocks^Δ10)

(Barton et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has decreased occurrence of cell division | larval stage phenotype

(Barton et al., 2014)

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has lethal phenotype

(Barton et al., 2014)

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has abnormal mitotic cell cycle phenotype

(Barton et al., 2014)

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has some die during P-stage phenotype

(Barton et al., 2014)

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has majority die during larval stage phenotype

(Barton et al., 2014)

MAN1^Δ26/MAN1^Δ81, bocks^Δ10/bocks^Δ66 has lethal phenotype

(Barton et al., 2014)

MAN1^Δ26/MAN1^Δ81, bocks^Δ10/bocks^Δ66 has some die during P-stage phenotype

(Barton et al., 2014)

MAN1^Δ26/MAN1^Δ81, bocks^Δ10/bocks^Δ66 has some die during larval stage phenotype

(Barton et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has imaginal disc phenotype

(Barton et al., 2014)

Ote^PK/Ote^B279, bocks^Δ10/bocks^Δ66 has embryonic/larval brain | larval stage phenotype

(Barton et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Ote^B279/Ote^PK ; bocks^Δ10/bocks^Δ66 larval brains are small, with few proliferating cells, and imaginal discs are small or absent.

MAN1^Δ81/MAN1^Δ26 ; bocks^Δ10/bocks^Δ66 larvae have normal sized brains and imaginal discs.

(Barton et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

bocks^Δ66

(Barton et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections