FlyBase Allele Report: Dmel\Hsepi[d12]

General Information

Symbol

Dmel\Hsepi^d12

Species

D. melanogaster

Name

FlyBase ID

FBal0294779

Feature type

allele

Associated gene

Dmel\Hsepi

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dejima et al., 2013)

Progenitor genotype

Cytology

Description

Imprecise excision of Hsepi^KG02877 results in deletion of exon 1 and most of exon 2 of Hsepi.

(Dejima et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Dejima et al., 2013)

increased mortality during development

(Dejima et al., 2013)

increased mortality during development (with Df(2R)cn88b)

(Dejima et al., 2013)

short lived

(Dejima et al., 2013)

viable

(Dejima et al., 2013)

Phenotype Manifest In

posterior crossvein

(Dejima et al., 2013)

posterior crossvein (with Hsepi^d13)

(Dejima et al., 2013)

wing sensillum

(Dejima et al., 2013)

wing vein

(Dejima et al., 2013)

wing vein (with Hsepi^d13)

(Dejima et al., 2013)

wing vein L5

(Dejima et al., 2013)

Detailed Description

Statement

Reference

Lethality of Hsepi^d12 homozygotes (18.3%) is equivalent to that of their deficiency transheterozygotes (Hsepi^d12/Df(2R)cn88b; 19.3%), indicating that this is a null allele.

Hsepi^d12 adult survivors show only modest morphological phenotypes, such as extra vein materials at the posterior crossvein region of the wing. The penetrance of this phenotype is 25% in males and 90% in females. This phenotype is also observed in Hsepi^d12/Hsepi^d13 transallelic mutants.

Despite the relatively normal development and fertility of Hsepi^d12 adult survivors, the longevity of mutant adults is remarkably shorter than wild-type. The median of adult longevity of Hsepi^d12 mutants is 27 days, whereas it is 63 days in wild-type.

Hsepi^d12 mutant ovarioles show the same number of stalk cells as in wild-type.

The overall morphology of Hsepi^d12 mutant testes is normal.

No abnormality is observed in longitudinal wing vein structures of Hsepi^d12 homozygous mutant flies.

No defects are found in tracheoblasts in Hsepi^d12 mutant wing discs.

(Dejima et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsepi^d12 is an enhancer of increased mortality during development phenotype of Hs6st^d770

(Dejima et al., 2013)

Hsepi^d12 is an enhancer of lethal phenotype of Hs6st^d770

(Dejima et al., 2013)

Hsepi^d12 is an enhancer of increased mortality during development phenotype of Hs2st^d267

(Dejima et al., 2013)

Hsepi^d12 is an enhancer of increased mortality during development phenotype of sfl⁰³⁸⁴⁴

(Dejima et al., 2013)

Other

Statement

Reference

Hsepi^d12, dally^gem has lethal phenotype

(Dejima et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsepi^d12 has wing vein phenotype, enhanceable by sfl[+]/sfl⁰³⁸⁴⁴

(Dejima et al., 2013)

Hsepi^d12 has wing vein L5 phenotype, enhanceable by sfl[+]/sfl⁰³⁸⁴⁴

(Dejima et al., 2013)

Suppressed by

Statement

Reference

Hsepi^d12 has wing sensillum phenotype, suppressible by dlp¹/dlp[+]

(Dejima et al., 2013)

Hsepi^d12 has wing sensillum phenotype, suppressible by Sdc⁴⁸/Sdc[+]

(Dejima et al., 2013)

Hsepi^d12 has wing vein L5 phenotype, suppressible by Hs6st[+]/Hs6st^d770

(Dejima et al., 2013)

NOT Suppressor of

Statement

Reference

Hsepi^d12 is a non-suppressor of stalk follicle cell phenotype of Hs2st^d267

(Dejima et al., 2013)

Hsepi^d12 is a non-suppressor of ovariole phenotype of Hs2st^d267

(Dejima et al., 2013)

Other

Statement

Reference

Hs2st^d267, Hs6st^GD3078, Hsepi^d12, Scer\GAL4^btl.PS has imaginal tracheoblast | temperature conditional phenotype

(Dejima et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Hs2st^d267 Hsepi^d12 double mutants exhibit an ovariole stalk cell phenotype similar to that in Hs2st^d267 single mutants.

A heterozygous dally^gem mutant in a Hsepi^d12 homozygous background results in a decreased number of chemosensory bristles.

A heterozygous dlp¹ or Sdc⁴⁸ background does not result in a decreased number of chemosensory bristles in Hsepi^d12 homozygous mutants.

Hsepi^d12; dally^gem double mutants are lethal.

Heterozygous sfl⁰³⁸⁴⁴ mutants in a Hsepi^d12 mutant background exhibit truncation of the longitudinal vein L5.

Hsepi^d12/Hsepi^d12; Hs6st^d770/+ mutants show a reduction of the wing vein L5.

Knockdown of Hs6st through expression of Hs6st^GD3078 under the control of Scer\GAL4^btl.PS at 25[o]C in a Hs2st^d267 Hsepi^d12 double mutant background severely interferes with tracheoblast formation.

Knockdown of Hs6st through expression of Hs6st^GD3078 under the control of Scer\GAL4^btl.PS at 25[o]C in a Hsepi^d12 mutant background severely interferes with tracheoblast formation

(Dejima et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Hsepi^d12

(Dejima et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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