FlyBase Allele Report: Dmel\CalpB[505]

General Information

Symbol

Dmel\CalpB⁵⁰⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0283066

Feature type

allele

Associated gene

Dmel\CalpB

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kókai et al., 2012)

Mutagen

P-element activity

(Kókai et al., 2012)

Progenitor genotype

P{EPgy2}CalpB^EY08042

(Kókai et al., 2012)

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a 1047bp deletion that removes the first 873bp of the CalpB coding sequence.

(Kókai et al., 2012)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Kókai et al., 2012)

viable

(Kókai et al., 2012)

Phenotype Manifest In

border follicle cell

(Kókai et al., 2012)

border follicle cell (with Df(3L)AC1)

(Kókai et al., 2012)

Detailed Description

Statement

Reference

Homozygous and CalpB⁵⁰⁵/Df(3L)AC1 females show a delay in border follicle cell migration, with 32-38% of border cells failing to complete migration to the anterior end of the oocyte by stage 10. 46% of border cells show delay in the dorsal movement of border cells which is normally seen after they reach the oocyte.

(Kókai et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

CalpA⁸⁰⁸/Df(2R)ED3716, CalpB⁵⁰⁵ has viable phenotype

(Kókai et al., 2012)

CalpA⁸⁰⁸/Df(2R)ED3716, CalpB⁵⁰⁵ has fertile phenotype

(Kókai et al., 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

CalpB⁵⁰⁵ has border follicle cell phenotype, enhanceable by rhea^NIG.6831R/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

CalpB⁵⁰⁵ has border follicle cell phenotype, enhanceable by if^NIG.9623R/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

CalpB⁵⁰⁵ has border follicle cell phenotype, enhanceable by mys^NIG.1560R/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

NOT Enhanced by

Statement

Reference

CalpB⁵⁰⁵ has border follicle cell phenotype, non-enhanceable by CalpA⁸⁰⁸/Df(2R)ED3716

(Kókai et al., 2012)

CalpB⁵⁰⁵ has border follicle cell phenotype, non-enhanceable by rhea^{R367A.H.UAS.GFP}/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

Suppressed by

Statement

Reference

CalpB⁵⁰⁵ has border follicle cell phenotype, suppressible by rhea^H.UASp.mGFP6/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

NOT suppressed by

Statement

Reference

CalpB⁵⁰⁵ has border follicle cell phenotype, non-suppressible by CalpA⁸⁰⁸/Df(2R)ED3716

(Kókai et al., 2012)

CalpB⁵⁰⁵ has border follicle cell phenotype, non-suppressible by rhea^{R367A.H.UAS.GFP}/Scer\GAL4^slbo.2.6

(Kókai et al., 2012)

Enhancer of

Statement

Reference

CalpB⁵⁰⁵ is an enhancer of border follicle cell phenotype of Scer\GAL4^slbo.2.6, rhea^NIG.6831R

(Kókai et al., 2012)

CalpB⁵⁰⁵ is an enhancer of border follicle cell phenotype of Scer\GAL4^slbo.2.6, if^NIG.9623R

(Kókai et al., 2012)

CalpB⁵⁰⁵ is an enhancer of border follicle cell phenotype of Scer\GAL4^slbo.2.6, mys^NIG.1560R

(Kókai et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The delay in border follicle cell migration seen in CalpB⁵⁰⁵ females is unaffected if they are also carrying CalpA⁸⁰⁸/Df(2R)ED3716.

Females expressing rhea^NIG.6831R under the control of Scer\GAL4^slbo.2.6 in a CalpB⁵⁰⁵ background show an increase in the severity of the border follicle cell migration defect compared to either CalpB⁵⁰⁵ single mutants or females expressing rhea^NIG.6831R under the control of Scer\GAL4^slbo.2.6 in a wild-type background.

Females expressing if^NIG.9623R under the control of Scer\GAL4^slbo.2.6 in a CalpB⁵⁰⁵ background show an increase in the severity of the border follicle cell migration defect compared to either CalpB⁵⁰⁵ single mutants or females expressing if^NIG.9623R under the control of Scer\GAL4^slbo.2.6 in a wild-type background.

Females expressing mys^NIG.1560R under the control of Scer\GAL4^slbo.2.6 in a CalpB⁵⁰⁵ background show an increase in the severity of the border follicle cell migration defect compared to either CalpB⁵⁰⁵ single mutants or females expressing mys^NIG.1560R under the control of Scer\GAL4^slbo.2.6 in a wild-type background.

Expression of rhea^{H.Scer\UAS.T:Avic\GFP-m6} under the control of Scer\GAL4^slbo.2.6 restores normal border follicle cell migration in CalpB⁵⁰⁵ females.

Expression of rhea^{R376A.H.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^slbo.2.6 has no effect on the border follicle cell migration defects seen in CalpB⁵⁰⁵ females.

(Kókai et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

CalpB⁵⁰⁵ is rescued by CalpB^+t5.6

(Kókai et al., 2012)

Comments

CalpB^+t5.6 rescues the border follicle cell migration defects of CalpB⁵⁰⁵ females.

(Kókai et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Availability

Stated to be lost.

(Kókai et al., 2012)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

CalpB⁵⁰⁵

(Kókai et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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