FB2024_03 , released June 25, 2024
Allele: Dmel\Taoeta
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General Information
Symbol
Dmel\Taoeta
Species
D. melanogaster
Name
FlyBase ID
FBal0281998
Feature type
allele
Associated gene
Dmel\Tao
Associated Insertion(s)
P{EP}EP1455
Carried in Construct
Also Known As
Tao-1eta, EP1455
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gomez et al., 2012)
Mutagen
ethyl methanesulfonate
(Gomez et al., 2012)
Progenitor genotype
P{EP}EP1455
(Gomez et al., 2012)
Associated Insertion(s)
P{EP}EP1455
Cytology
Description

Nucleotide substitution: C?T.

(Gomez et al., 2012)

Amino acid replacement: Q64term.

(Gomez et al., 2012)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:19,577,305..19,577,305 [-]
Nucleotide change:

C19577305T

Reported nucleotide change:

C?T

Amino acid change:

Q64term | Tao-PD; Q64term | Tao-PE; Q64term | Tao-PF; Q64term | Tao-PH; Q64term | Tao-PI; Q64term | Tao-PJ

Reported amino acid change:

Q64term

(Gomez et al., 2012)
transposable_element_insertion_site
X:19,579,668..19,579,668 [-]
(Gomez et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autism spectrum disorder
      CEA
      (Hu et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The size of Taoeta mutant intestinal stem cell clones is increased compared to controls.

      (Huang et al., 2014)

      Homozygous follicle cell clones produce defects in the follicular epithelium. During stage 8/9, homozygous cells in the anterior follicular epithelium fail to stretch and stay cuboidal, in contrast to wild type. Posterior clones show milder defects, showing an increase in the length of the lateral membrane compared to wild type.

      (Gomez et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      Taoeta has follicle cell | somatic clone phenotype, non-suppressible by crbGD14463/Scer\GAL4GR1

      (Gomez et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The failure of anterior follicle cells in homozygous Taoeta stage 9 follicle cell clones to stretch is suppressed in approximately 50% of cases if the clones are also expressing Fas2KK100888 under the control of Scer\GAL4GR1.

      The failure of anterior follicle cells in homozygous Taoeta stage 9 follicle cell clones to stretch is not suppressed if the clones are also expressing crbGD14463 under the control of Scer\GAL4GR1.

      (Gomez et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Taoeta is rescued by Scer\GAL4Tub.PU/TaoUAS.cGa

      (Gomez et al., 2012)

      Taoeta is rescued by TaoUAS.cGa/Scer\GAL4GR1

      (Gomez et al., 2012)

      Taoeta is rescued by TaoUAS.Tag:HA/Scer\GAL4GR1

      (Gomez et al., 2012)
      Comments

      Expression of TaoScer\UAS.cGa under the control of Scer\GAL4tub.PU rescues the lethality of Taoeta homozygotes.

      Expression of either TaoScer\UAS.cGa or TaoScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GR1 rescues the defects in follicle epithelium morphology seen in homozygous Taoeta follicle cell clones.

      Large follicle cell clones doubly homozygous for Taoeta and Fas2EB112 show cell lethality, while small follicle cell clones doubly homozygous for Taoeta and Fas2EB112 can be recovered in stage 8/9 egg chambers. Anterior follicle cells in these small clones stretch normally.

      (Gomez et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Tao-1eta
      (Fletcher et al., 2018, Poon et al., 2018)
      Taoeta
      (Hu et al., 2020, Fletcher et al., 2018, Poon et al., 2018, Huang et al., 2014, Gomez et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)