FlyBase Allele Report: Dmel\Trl[109.2]

General Information

Symbol

Dmel\Trl^109.2

Species

D. melanogaster

Name

FlyBase ID

FBal0280394

Feature type

allele

Associated gene

Dmel\Trl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Greenberg and Schedl, 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

homeotic (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

lethal (with Trl^81.1)

(Greenberg and Schedl, 2001)

lethal (with Trl^R67)

(Greenberg and Schedl, 2001)

partially lethal - majority die | maternal effect (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

partially lethal - majority die | maternal effect (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

semi-fertile (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

semi-fertile (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

some die during embryonic stage | maternal effect (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

some die during embryonic stage | maternal effect (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

Phenotype Manifest In

abdominal segment 5 | ectopic (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

abdominal segment 5 | ectopic (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

abdominal segment 6 (with Trl^81.1), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

abdominal segment 6 (with Trl^R67), with Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

Detailed Description

Statement

Reference

All surviving male flies expressing Trl^{Hsp83.GAGA-581} in a Trl^109.2/Trl^R67 mutant background show a transformation of the sixth abdominal segment towards the fifth.

Trl^109.2/Trl^R67 mutant females expressing four copies of Trl^{Hsp83.GAGA-581} exhibit egg laying defects, laying approximately 12 eggs per 24 hours, compared to around 25 in wild type.

Approximately 40% of embryos produced by Trl^109.2/Trl^R67 mutant females expressing four copies of Trl^{Hsp83.GAGA-581} are able to hatch. None of the embryos show any defects in nuclear division and the nuclear monolayer is intact.

Approximately 20% of surviving male flies expressing Trl^{Hsp83.GAGA-519} in a Trl^109.2/Trl^18.1 mutant background show a transformation of the sixth abdominal segment towards the fifth.

Trl^109.2/Trl^18.1 mutant females expressing four copies of Trl^{Hsp83.GAGA-519} exhibit egg laying defects, laying approximately 12 eggs per 24 hours, compared to around 25 in wild type.

Approximately 70% of embryos produced by Trl^109.2/Trl^18.1 mutant females expressing four copies of Trl^{Hsp83.GAGA-519} are able to hatch.

(Greenberg and Schedl, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Trl^R67/Trl^109.2 is partially rescued by Trl^{Hsp83.GAGA-581}

(Greenberg and Schedl, 2001)

Trl^R67/Trl^109.2 is partially rescued by Trl^{Hsp83.GAGA-519}/Trl^{Hsp83.GAGA-581}

(Greenberg and Schedl, 2001)

Trl^81.1/Trl^109.2 is partially rescued by Trl^{Hsp83.GAGA-519}

(Greenberg and Schedl, 2001)

Trl^81.1/Trl^109.2 is partially rescued by Trl^{Hsp83.GAGA-519}/Trl^{Hsp83.GAGA-581}

(Greenberg and Schedl, 2001)

Comments

Expression of one or two copies of Trl^{Hsp83.GAGA-519} has no effect on the lethality associated with Trl^109.2/Trl^18.1 mutants. However expression of four copies is able to partially rescue the phenotype, with 10% of flies surviving.

Expression of two copies of Trl^{Hsp83.GAGA-519} and two copies of Trl^{Hsp83.GAGA-581} partially rescues the lethality associated with Trl^109.2/Trl^18.1 mutants, with approximately 40% of flies surviving.

Expression of one or two copies of Trl^{Hsp83.GAGA-581} has no effect on the lethality associated with Trl^109.2/Trl^R67 mutants. However expression of four copies is able to partially rescue the phenotype, with 80% of flies surviving.

Expression of two copies of Trl^{Hsp83.GAGA-519} and two copies of Trl^{Hsp83.GAGA-581} partially rescues the lethality associated with Trl^109.2/Trl^R67 mutants, with approximately 70% of flies surviving.

(Greenberg and Schedl, 2001)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Trl^109.2

(Greenberg and Schedl, 2001)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

Open Close