FlyBase Allele Report: Dmel\rl[Sem.cUa.UAS]

General Information

Symbol

Dmel\rl^Sem.cUa.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0276790

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

P{UAS-rl.Sem.U}

Also Known As

UAS-rl^SEM, UAS-Erk^sem, UAS-Sem, rl^SEM, UAS-rl(sem)

Key Links

Transgenic product class

missense_variant

(Jones et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Jones et al., 2012)

Mutagen

in vitro construct

(Jones et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-rl.Sem.U}

Cytology

Description

UAS regulatory sequences drive expression of rl(sem).

(Jones et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

increased cell number | adult stage, with Scer\GAL4^sev.PU

(Kim et al., 2004)

visible, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

visible | adult stage, with Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

eye photoreceptor cell | adult stage | increased number, with Scer\GAL4^GMR.PU

(Aron et al., 2010)

eye photoreceptor cell | adult stage | increased number, with Scer\GAL4^sev.PU

(Kim et al., 2004)

tracheal branch primordium, with Scer\GAL4^btl.PS

(Cela and Llimargas, 2006)

wing vein, with Scer\GAL4^Bx-MS1096

(Hasson et al., 2005)

wing vein | ectopic, with Scer\GAL4^bs-1348

(Ruiz-Gomez et al., 2005)

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

(Guichard et al., 2006)

wing vein | ectopic, with Scer\GAL4^salm.EPv

(Molnar and de Celis, 2013)

Detailed Description

Statement

Reference

The expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^C587 does not lead to significant changes in the numbers of germ line stem cells and cystoblasts in the germarium, as compared to controls.

(Ma et al., 2014)

Flies with expression of rl^Sem.cUa.UAS driven by Scer\GAL4^GMR.PU have a rough eye phenotype, with a significant increase in the number of R cells per ommatidium.

(Aron et al., 2010)

Expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^btl.PS results in a branching extension delay in 27% of embryonic dorsal branches and incomplete or impaired cell intercalation.

(Cela and Llimargas, 2006)

Expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^Bx-MS1096 results in ectopic wing veins.

(Guichard et al., 2006)

The expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^Bx-MS1096 leads to the formation of extra wing vein material.

(Hasson et al., 2005)

Expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^bs-1348 induces differentiation of ectopic wing vein tissue.

(Ruiz-Gomez et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has increased cell number | adult stage phenotype, non-enhanceable by dj-1β^UAS.cMa/Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has visible phenotype, non-enhanceable by dj-1β^UAS.cMa/Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has increased cell number | adult stage phenotype, non-enhanceable by DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has visible phenotype, non-enhanceable by DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^sev.PU, rl^Sem.cUa.UAS has increased cell number | adult stage phenotype, non-enhanceable by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^salm.EPv, rl^Sem.cUa.UAS has visible | adult stage phenotype, suppressible | partially by Scer\GAL4^salm.EPv/tay^EP-866

(Molnar and de Celis, 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has increased cell number | adult stage phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has visible phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Scer\GAL4^sev.PU, rl^Sem.cUa.UAS has increased cell number | adult stage phenotype, non-suppressible by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

NOT Enhancer of

Statement

Reference

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PU is a non-enhancer of visible | adult stage phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Suppressor of

Statement

Reference

rl^Sem.cUa.UAS/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, Vpar\VopA^UAS.Tag:MYC

(Jones et al., 2008)

NOT Suppressor of

Statement

Reference

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

rl^Sem.cUa.UAS/Scer\GAL4^αTub84B.PL is a non-suppressor of increased cell death | somatic clone phenotype of Slik¹

(Hipfner and Cohen, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^salm-459.2, rl^Sem.cUa.UAS has wing vein | ectopic phenotype, enhanceable by osa[+]/osa³⁰⁸

(Terriente-Félix and de Celis, 2009)

Scer\GAL4^salm-459.2, rl^Sem.cUa.UAS has wing vein | ectopic phenotype, enhanceable by osa^UAS.cCa/Scer\GAL4^salm-459.2

(Terriente-Félix and de Celis, 2009)

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye phenotype, non-enhanceable by dj-1β^UAS.cMa/Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye photoreceptor cell | adult stage | increased number phenotype, non-enhanceable by dj-1β^UAS.cMa/Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye phenotype, non-enhanceable by DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye photoreceptor cell | adult stage | increased number phenotype, non-enhanceable by DJ-1α^UAS.cMa, Scer\GAL4^GMR.PU

(Aron et al., 2010)

Scer\GAL4^sev.PU, rl^Sem.cUa.UAS has eye photoreceptor cell | adult stage | increased number phenotype, non-enhanceable by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Suppressed by

Statement

Reference

Scer\GAL4^salm.EPv, rl^Sem.cUa.UAS has wing vein | ectopic phenotype, suppressible | partially by Scer\GAL4^salm.EPv/tay^EP-866

(Molnar and de Celis, 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Scer\GAL4^GMR.PU, rl^Sem.cUa.UAS has eye photoreceptor cell | increased number | adult stage phenotype, non-suppressible by dj-1β^Δ93/dj-1beta[+]

(Aron et al., 2010)

Scer\GAL4^Bx-MS1096, rl^Sem.cUa.UAS has wing vein | ectopic phenotype, non-suppressible by Bant\lef^UAS.cGa, Scer\GAL4^Bx-MS1096

(Guichard et al., 2006)

Scer\GAL4^Bx-MS1096, rl^Sem.cUa.UAS has wing vein phenotype, non-suppressible by E(spl)mβ-HLH^UAS.cdCa, Scer\GAL4^Bx-MS1096

(Hasson et al., 2005)

Scer\GAL4^Bx-MS1096, rl^Sem.cUa.UAS has wing vein phenotype, non-suppressible by Scer\GAL4^Bx-MS1096/gro^UAS.cAa

(Hasson et al., 2005)

Scer\GAL4^sev.PU, rl^Sem.cUa.UAS has eye photoreceptor cell | increased number | adult stage phenotype, non-suppressible by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Enhancer of

Statement

Reference

rl^Sem.cUa.UAS/Scer\GAL4^dpp.blk1 is an enhancer of eye | ectopic phenotype of Scer\GAL4^dpp.blk1, eya^UAS.cHa

(Hsiao et al., 2001)

rl^Sem.cUa.UAS/Scer\GAL4^dpp.PH is an enhancer of wing phenotype of Scer\GAL4^dpp.PH, eya^UAS.cHa

(Hsiao et al., 2001)

NOT Enhancer of

Statement

Reference

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Suppressor of

Statement

Reference

rl^Sem.cUa.UAS/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Vpar\VopA^UAS.Tag:MYC

(Jones et al., 2008)

rl^Sem.cUa.UAS, Scer\GAL4^btl.PS is a suppressor of dorsal tracheal branch primordium phenotype of Mkp3^GS801, Scer\GAL4^btl.PS

(Cela and Llimargas, 2006)

rl^Sem.cUa.UAS, Scer\GAL4^btl.PS is a suppressor of ganglionic tracheal branch primordium phenotype of Mkp3^GS801, Scer\GAL4^btl.PS

(Cela and Llimargas, 2006)

rl^Sem.cUa.UAS, Scer\GAL4^btl.PS is a suppressor of tracheal branch primordium phenotype of Mkp3^GS801, Scer\GAL4^btl.PS

(Cela and Llimargas, 2006)

rl^Sem.cUa.UAS, Scer\GAL4^dpp.3KK is a suppressor of wing vein phenotype of Mkp3^EP-M76, Scer\GAL4^dpp.3KK

(Ruiz-Gomez et al., 2005)

NOT Suppressor of

Statement

Reference

rl^Sem.cUa.UAS, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

rl^Sem.cUa.UAS/Scer\GAL4^Bx-MS1096 is a non-suppressor of wing vein phenotype of Scer\GAL4^Bx-MS1096, gro^AA.UAS

(Hasson et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of tay^EP-866 partially suppresses the ectopic wing vein phenotype seen when rl^Sem.cUa.UAS is expressed under the control of Scer\GAL4^salm.EPv.

(Molnar and de Celis, 2013)

Co-expression of DJ-1α^UAS.cMa or dj-1β^UAS.cMa or presence of dj-1β^Δ93/+ does not alter eye phenotypes in flies with expression of rl^Sem.cUa.UAS driven by Scer\GAL4^GMR.PU.

(Aron et al., 2010)

The formation of ectopic wing veins in flies expressing rl^Sem.cUa.UAS under the control of Scer\GAL4^salm-459.2 is weakly enhanced in a osa³⁰⁸/+ mutant background, but strongly enhanced by over-expression of osa^UAS.cCa.

(Terriente-Félix and de Celis, 2009)

Coexpression of rl^Sem.cUa.UAS suppresses the tracheal branching defects of Scer\GAL4^btl.PS>Mkp3^GS801 embryos.

(Cela and Llimargas, 2006)

Coexpression of rl^Sem.cUa.UAS and E(spl)mβ-HLH^UAS.cdCa, under the control of Scer\GAL4^Bx-MS1096, results in wing vein thickening that is indistinguishable from expression of rl^Sem.cUa.UAS alone. Likewise, coexpression of gro^UAS.cAa with rl^Sem.cUa.UAS, under the control of Scer\GAL4^Bx-MS1096, is unable to suppress the thick wing vein phenotype. Coexpression of rl^Sem.cUa.UAS and gro^AA.UAS, under the control of Scer\GAL4^Bx-MS1096, results in wings with little vein material, similar to the phenotype when only gro^AA.UAS is expressed.

(Hasson et al., 2005)

Expression of rl^Sem.cUa.UAS under the control of Scer\GAL4^dpp.3KK suppresses the loss of wing vein phenotype of Scer\GAL4^dpp.3KK>Mkp3^EP-M76 flies.

(Ruiz-Gomez et al., 2005)

Ectopic eyes in eya^UAS.cHa; Scer\GAL4^dpp.blk1; rl^Sem.cUa.UAS are generally larger, and have more ommatidial definition than those in eya^UAS.cHa; Scer\GAL4^dpp.blk1 flies. The proportion of eya^UAS.cHa; Scer\GAL4^dpp.PH flies with blistered wings (76%) is increased by heterozygosity for rl^Sem.cUa.UAS to 93%, while the proportion with only mild wing defects is decreased from 24% to 7%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

(Hsiao et al., 2001)

Xenogenetic Interactions

Statement

Reference

The additional co-expression of rl^Sem.cUa.UAS does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6^UAS.Tag:MYC and Hsap\UBE3A^UAS.cRa under the control of Scer\GAL4^GMR.PU.

(Padash Barmchi et al., 2016)

Co-expression of rl^{sem.cUa.Scer\UAS} with Zzzz\aopP^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF does not alter the eye morphology of Zzzz\aopP^{Scer\UAS.T:Hsap\MYC}-expressing eyes.

Co-expression of rl^{sem.cUa.Scer\UAS} with Zzzz\VopA^Scer\UAS.cJa under the control of Scer\GAL4^GMR.PF completely suppresses the rough eye phenotype resulting from the expression of Zzzz\VopA^Scer\UAS.cJa.

(Jones et al., 2012)

Expression of rl^{sem.cUa.Scer\UAS} suppresses the rough eye phenotype seen when Zzzz\VopA^{Scer\UAS.T:Hsap\MYC} is expressed under the control of Scer\GAL4^GMR.PF.

(Jones et al., 2008)

Expression of Bant\lef^UAS.cGa does not suppress the ectopic vein phenotype of rl^Sem.cUa.UAS under the control of Scer\GAL4^Bx-MS1096.

(Guichard et al., 2006)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

rl^SEM

(Ma et al., 2014)

rl^{Sem.cUa.Scer\UAS}

rl^Sem.cUa.UAS

rl^{sem.cUa.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (25)

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