FB2024_03 , released June 25, 2024
Allele: Dmel\groAA.UAS
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General Information
Symbol
Dmel\groAA.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0179597
Feature type
allele
Associated gene
Dmel\gro
Associated Insertion(s)
Carried in Construct
P{UAS-gro.AA}
Also Known As
UAS-GroAA
Key Links
Transgenic product class
missense_variant
(Hasson et al., 2005)
polypeptide_post_translational_processing_variant
(Hasson et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hasson et al., 2005)
polypeptide_post_translational_processing_variant
(Hasson et al., 2005)
Mutagen
in vitro construct
(Hasson et al., 2005)
Progenitor genotype
groUAS.cAa
(Hasson et al., 2005)
Carried in construct
P{UAS-gro.AA}
Cytology
Description

Two putative MAPK phosphorylation sites have been mutated. The changes are PGTP to PGAP and LASP to LAAP.

(Hasson et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
gro
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of groAA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 eliminates all veins in the wing. Expression of groAA.Scer\UAS, under the control of Scer\GAL4sca-C253, results in the loss of bristles on the notum.

      (Hasson et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4sca-C253, groAA.UAS has mesothoracic tergum & macrochaeta phenotype, non-suppressible by Scer\GAL4sca-C253/btl::Egfrλ.UAS

      (Hasson et al., 2005)

      Scer\GAL4Bx-MS1096, groAA.UAS has wing vein phenotype, non-suppressible by rlSem.cUa.UAS/Scer\GAL4Bx-MS1096

      (Hasson et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Coexpression of rlSem.cUa.UAS and groAA.UAS, under the control of Scer\GAL4Bx-MS1096, results in wings with little vein material, similar to the phenotype when only groAA.UAS is expressed. Coexpression of btl::Egfrλ.UAS with groAA.UAS, under the control of Scer\GAL4sca-C253, is unable to suppress the loss of notal bristle phenotype seen when groAA.UAS alone is expressed.

      (Hasson et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      groAA.Scer\UAS
      groAA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)