FlyBase Allele Report: Dmel\asrij[9]

General Information

Symbol

Dmel\asrij⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0269376

Feature type

allele

Associated gene

Dmel\asrij

Associated Insertion(s)

Carried in Construct

Also Known As

arj⁹, arj9

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Kulkarni et al., 2011)

Mutagen

P-element activity

(Kulkarni et al., 2011)

Progenitor genotype

P{SUPor-P}asrij^KG08071

(Kulkarni et al., 2011)

Cytology

Description

Imprecise excision of the progenitor insertion.

(Kulkarni et al., 2011)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate

(Sinha et al., 2013)

abnormal mitotic cell cycle

(Kulkarni et al., 2011)

fertile

(Kulkarni et al., 2011)

increased cell number | third instar larval stage

(Ray et al., 2021)

viable

(Kulkarni et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

In the asrij⁹/asrij⁹ third instar larval lymph gland, mitochondria show increased branch length, footprint (content), number of branches, number of junctions and aggregation. The lymph gland shows an increase in crystal cells in the primary lobe.

(Ray et al., 2021)

Hemocytes from asrij⁹ homozygous mutant larvae do not display any obvious defects in their phagocytic ability.

(Khadilkar et al., 2017)

asrij⁹ mutants show premature differentiation to P1+ plasmatocytes.

(Sinha et al., 2013)

Homozygous third instar larvae have a higher number of secondary lymph gland lobes than normal which expand into posterior segments up to A4 or A5 (excess secondary lobes are not seen in mutant embryos or second instar larvae). The mutant ectopic lobes are asymmetric and extend up to three quarters of the length of the dorsal vessel.

The number of mitotic foci in the primary lymph gland lobe of mutant third instar larvae is normal, but there is a dramatic increase in the number of mitotic foci in the secondary lymph gland lobes at this stage.

The primary lymph gland lobe of mutant third instar larvae show premature loss of the medullary zone and hemocyte differentiation compared to controls.

The total number of circulating hemocytes is significantly increased in mutant third instar larvae compared to wild type.

(Kulkarni et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

asrij⁹ has increased cell number | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has increased cell number | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

Suppressed by

Statement

Reference

asrij⁹ has abnormal developmental rate phenotype, suppressible by Scer\GAL4^e33C/Mmus\Cd8a^UAS.cLa.EGFP

(Sinha et al., 2013)

Enhancer of

Statement

Reference

asrij⁹/asrij⁹ is an enhancer of increased cell number | third instar larval stage phenotype of Marf^JF01650, Scer\GAL4^e33C

(Ray et al., 2021)

asrij⁹/asrij⁹ is an enhancer of increased cell number | third instar larval stage phenotype of Drp1^UAS.cDa, Scer\GAL4^e33C

(Ray et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

asrij⁹ has embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has primary lobe of embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

asrij⁹ has primary lobe of embryonic/larval lymph gland | third instar larval stage phenotype, enhanceable by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

Suppressed by

Statement

Reference

asrij⁹ has mitochondrion | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

asrij⁹ has prohemocyte | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

asrij⁹ has embryonic/larval lymph gland | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Drp1^UAS.cDa

(Ray et al., 2021)

asrij⁹ has mitochondrion | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has prohemocyte | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has embryonic/larval lymph gland | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^e33C/Marf^JF01650

(Ray et al., 2021)

asrij⁹ has embryonic/larval plasmatocyte phenotype, suppressible by Scer\GAL4^e33C/Mmus\Cd8a^UAS.cLa.EGFP

(Sinha et al., 2013)

Enhancer of

Statement

Reference

asrij⁹/asrij⁹ is an enhancer of embryonic/larval lymph gland | third instar larval stage phenotype of Drp1^UAS.cDa, Scer\GAL4^e33C

(Ray et al., 2021)

asrij⁹/asrij⁹ is an enhancer of embryonic/larval crystal cell | third instar larval stage | increased number phenotype of Drp1^UAS.cDa, Scer\GAL4^e33C

(Ray et al., 2021)

asrij⁹/asrij⁹ is an enhancer of embryonic/larval crystal cell | third instar larval stage | increased number phenotype of Marf^JF01650, Scer\GAL4^e33C

(Ray et al., 2021)

asrij⁹/asrij⁹ is an enhancer of embryonic/larval lymph gland | third instar larval stage phenotype of Marf^JF01650, Scer\GAL4^e33C

(Ray et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Transgenic flies that express Scer\GAL4^e33C>Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} in asrij⁹ mutants show complete suppression of premature plasmatocyte differentiation.

(Sinha et al., 2013)

Complementation and Rescue Data

Rescued by

asrij⁹ is rescued by asrij^N.UAS/Scer\GAL4^e33C

(Sinha et al., 2013)

Partially rescued by

asrij⁹ is partially rescued by Scer\GAL4^e33C/asrij^UAS.cKa

(Kulkarni et al., 2011)

asrij⁹ is partially rescued by Scer\GAL4^Hml.PG/asrij^UAS.cKa

(Kulkarni et al., 2011)

Not rescued by

asrij⁹ is not rescued by Scer\GAL4^e33C/asrij^C.UAS

(Sinha et al., 2013)

Comments

Expression of asrij^Scer\UAS.cKa under the control of either Scer\GAL4^e33C or Scer\GAL4^Hml.PG restores lymph gland lobe number and pericardial cell arrangement to a near wild-type pattern in asrij⁹ third instar larvae.

(Kulkarni et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

arj9

(Ray et al., 2021, Sinha et al., 2013)

arj⁹

(Rodrigues et al., 2021, Khadilkar et al., 2017, Kulkarni et al., 2011)

asrij⁹

Name Synonyms

Secondary FlyBase IDs

References (6)

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