FlyBase Allele Report: Dmel\polybromo[33.2]

General Information

Symbol

Dmel\polybromo^33.2

Species

D. melanogaster

Name

FlyBase ID

FBal0261207

Feature type

allele

Associated gene

Dmel\polybromo

Associated Insertion(s)

P{}polybromo^33.2

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Chalkley et al., 2008)

Progenitor genotype

Associated Insertion(s)

P{}polybromo^33.2

Cytology

Description

Obtained by P-element insertion mapping at the 10- to 40-bp position upstream of the first ATG codon of the polybromo gene.

(Chalkley et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Chalkley et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes are viable with no apparent phenotype.

(Chalkley et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

polybromo^33.2/polybromo[+] is an enhancer of partially lethal - majority die | recessive | male limited phenotype of Bap170^G5986

(Chalkley et al., 2008)

Other

Statement

Reference

Bap170^G5986, polybromo^33.2 has lethal phenotype

(Chalkley et al., 2008)

Phenotype Manifest In

Enhancer of

Statement

Reference

polybromo^33.2, Bap170[+], Bap170^G5986, polybromo[+] is an enhancer of leg phenotype of e(y)3⁴

(Chalkley et al., 2008)

polybromo^33.2/polybromo[+] is an enhancer of leg phenotype of Bap170^G5986

(Chalkley et al., 2008)

Suppressor of

Statement

Reference

polybromo^33.2, Bap170[+], Bap170^G5986, polybromo[+] is a suppressor of sex comb | ectopic phenotype of Pc¹

(Chalkley et al., 2008)

polybromo^33.2, Bap170[+], Bap170^G5986, polybromo[+] is a suppressor of sex comb | ectopic phenotype of Pc³

(Chalkley et al., 2008)

Other

Statement

Reference

Bap170^G5986, polybromo^33.2 has leg phenotype

(Chalkley et al., 2008)

Bap170^G5986, polybromo^33.2 has head phenotype

(Chalkley et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

The combination of Bap170^G5986/+ with polybromo^33.2/+ act as strong dominant enhancers of the penetrance of the e(y)3⁴/Y bent-leg phenotype in male flies.

polybromo^33.2/+ further reduces Bap170^G5986 viability and enhances its leg malformation phenotype.

The frequency of posterior-to-anterior leg transformations is reduced in transheterozygous males when Pc¹ or Pc³ is combined with both Bap170^G5986/+ and polybromo^33.2/+.

(Chalkley et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

polybromo^33.2

(Chalkley et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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