FB2024_03 , released June 25, 2024
Allele: Dmel\paraJS1
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General Information
Symbol
Dmel\paraJS1
Species
D. melanogaster
Name
FlyBase ID
FBal0243136
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
P{lacW}paraJS1
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Song and Tanouye, 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{lacW}paraJS1
    Cytology
    Description

    P{lacW}paraJS1 is inserted 6,845bp downstream of the para coding region.

    (Song and Tanouye, 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{lacW}
    Encoded product / tool
    lacZ
    Tagged with
    Tag:NLS(P)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The seizure threshold (minimum voltage of high frequency stimulation of the brain required to induce seizure) paraJS1 homozygous flies is higher than that of wild-type flies. This is reduced to wild-type levels by Tp(1;2)r+75c/+.

        Flies carrying paraJS1 in trans to Df(1)D34, parahd5, paraID30, paraID7 or paralk2 are viable but exhibit paralysis after heat shock. Flies carrying paraJS1 in trans to parats1, paraST76 or parats115 are viable and do not exhibit paralysis following heat shock.

        (Song and Tanouye, 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        paraJS1, mlenap-ts1, para[+] is a suppressor of bang sensitive | recessive phenotype of eas2

        (Song and Tanouye, 2007)

        paraJS1/para[+] is a suppressor of bang sensitive | recessive phenotype of eas2

        (Song and Tanouye, 2007)

        paraJS1/para[+] is a suppressor of bang sensitive phenotype of jusiso7.8

        (Song and Tanouye, 2007)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        paraJS1 dominantly suppresses the bang sensitive phenotype of eas2 homozygotes by 87%. The minimum voltage of high frequency stimulation of the brain required to induce seizure (the seizure threshold) of eas2 homozygotes is raised to almost wild-type levels by paraJS1/+. This suppression is itself suppressed by Tp(1;2)r+75c/+.

        paraJS1/+; mlenap-ts1/+ completely suppresses the bang sensitive phenotype of eas2 homozygotes and increases the minimum voltage of high frequency stimulation of the brain required to induce seizure to wild-type levels.

        Neither para13.5.Scer\UAS; Scer\GAL4elav.PLu nor para13.5.Scer\UAS; Scer\GAL4elav.PLu reduces suppression of bang sensitivity and seizure threshold reduction of eas2 homozygotes by paraJS1/+.

        (Song and Tanouye, 2007)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Despite the closer proximity of P{lacW}paraJS1 to Rbp2, this insertion is considered a para allele based on reduction of para transcript but not Rbp2 and on phenotype. However, it does complement a number of para alleles.

        (Song and Tanouye, 2007)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        paraJS1
        (Song and Tanouye, 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)