FB2024_03 , released June 25, 2024
Allele: Dmel\parats115
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General Information
Symbol
Dmel\parats115
Species
D. melanogaster
Name
FlyBase ID
FBal0013495
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
?{}parats115
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Pittendrigh et al., 1997)
Progenitor genotype
Associated Insertion(s)
?{}parats115
Cytology
Description

Insertion and deletion? break at 8-9 kb.

(Lindsley and Zimm, 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  epilepsy
      CEA with parats1
      (Fergestad et al., 2006)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  epilepsy
      modeled by paraShu
      (Kaas et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      parats115 homozygotes are viable but exhibit paralysis following heat shock. parats115/paraJS1 flies are also viable but do not exhibit paralysis following heat shock.

      (Song and Tanouye, 2007)

      parats1/parats115 flies do not show a significantly shortened lifespan. However, the brains of these flies show neurodegeneration.

      (Fergestad et al., 2006)

      parats115 mutant larvae do not display any resistance to picrotoxin (PTX)-induced seizures.

      (Stilwell et al., 2006)

      Homozygous flies do not show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies.

      (Pittendrigh et al., 1997)

      Viability of double mutant males with mlenap-ts1 is significantly reduced, even at permissive temperatures. Double mutant males at 25oC die at or near eclosion.

      (Ganetzky, 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      parats115/para[+] is an enhancer of short lived | dominant phenotype of AtpαDTS1

      (Fergestad et al., 2006)
      Other
      Statement
      Reference

      AtpαDTS2, parats115 has short lived phenotype

      (Fergestad et al., 2006)

      mlenap-ts1, parats115 has partially lethal phenotype

      (Ganetzky, 1984)

      mlenap-ts1, parats115 has lethal | heat sensitive phenotype

      (Ganetzky, 1984)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The short lived phenotype of AtpαDTS1 heterozygotes is enhanced in parats115/+ flies. parats115; AtpαDTS2 double mutants also have a short lifespan of <1 week.

      (Fergestad et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      paraShu/parats115 transheterozygous female adults reared at 25[o]C temperature exhibit strong decreases in wing posture defects and in the movement time spent in the centre of a circular space, as compared to paraShu heterozygous females.

      (Kaas et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements nonA9 in females heterozygous for both mutations.

      (Kulkarni et al., 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      para115
      (Stilwell et al., 2006)
      parats115
      (Kaas et al., 2016, Song and Tanouye, 2007, Stilwell et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)