FlyBase Allele Report: Dmel\Dg[O38]

General Information

Symbol

Dmel\Dg^O38

Species

D. melanogaster

Name

FlyBase ID

FBal0218111

Feature type

allele

Associated gene

Dmel\Dg

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Christoforou et al., 2008)

Progenitor genotype

Cytology

Description

Deletion of 653bp, beginning at position 2499 of exon 11 and ending in the intron between exons 11 and 12. This introduces a termination codon three amino acid residues after V625.

(Christoforou et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:16,083,925..16,084,577 [-]

Comment:

Deletion of 653bp, beginning at position 2499. Results in a stop codon three amino acids after V625. Reported coordinates appear to be relative to GB:GH09323.

(Christoforou et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die (with Dg^O55)

(Yatsenko et al., 2014)

partially lethal - majority live

(Christoforou et al., 2008)

partially lethal - majority live (with Df(2R)ED2457)

(Christoforou et al., 2008)

partially lethal - majority live (with Dg^J43)

(Christoforou et al., 2008)

viable (with Dg²⁴⁸)

(Mirouse et al., 2009)

viable (with Dg³²³)

(Mirouse et al., 2009)

viable (with Dg^O43)

(Mirouse et al., 2009)

viable (with Dg^O55)

(Mirouse et al., 2009)

viable (with Dg^O86)

(Mirouse et al., 2009)

visible (with Dg^J43)

(Christoforou et al., 2008)

Phenotype Manifest In

crossvein (with Dg^J43)

(Christoforou et al., 2008)

Detailed Description

Statement

Reference

The Dg[-] progeny of Dg^O38/Dg^O86 females mated to Dg^O43/+ males are viable when grown without competition from heterozygous larvae.

The Dg[-] progeny of Dg^O55/Dg^O86 females mated to Dg^O38/+ males are viable when grown without competition from heterozygous larvae.

Dg^O86/Dg^O38 animals show reduced viability under normal culture conditions.

73% of eggs laid by Dg^O38/Dg^O86 females mated to wild-type males hatch.

85% of eggs laid by Dg^O38/Dg^O86 females mated to Dg^O43/+ males hatch.

82% of eggs laid by Dg^O55/Dg^O86 females mated to Dg^O38/+ males hatch.

(Mirouse et al., 2009)

Homozygotes show a posterior crossvein phenotype with 100% penetrance. More than 90% of wings show a "detached" phenotype (the crossvein is detached from both L4 and L5). A small fraction of wings with a "gapped" phenotype (the crossvein is detached from either vein L4 or L5, but not both) are seen.

Dg^O38/Df(2R)ED2457 animals show 64% viability compared to controls.

(Christoforou et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Dg^O38

(Yatsenko et al., 2014, Mirouse et al., 2009, Mirouse et al., 2009, Christoforou et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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