FlyBase Allele Report: Dmel\asrij[GD2167]

General Information

Symbol

Dmel\asrij^GD2167

Species

D. melanogaster

Name

FlyBase ID

FBal0209089

Feature type

allele

Associated gene

Dmel\asrij

Associated Insertion(s)

Carried in Construct

P{GD2167}

Also Known As

UAS arj rnai

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2167}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2167

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage, with Scer\GAL4^e33C

(Khadilkar et al., 2017)

abnormal immune response | adult stage, with Scer\GAL4^Hml.PU

(Khadilkar et al., 2017)

increased cell number | third instar larval stage, with Scer\GAL4^dome-PG14

(Ray et al., 2021)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Drp1^GD10456 under the control of Scer\GAL4^dome-PG14 leads to the blood progenitors in the third instar larva lymph gland to show mitochondria with longer branches; the mitochondrial footprint and number of junctions is increased in the primary lobe, and decreased in the secondary lobe. The lymph gland shows an increase in crystal cells in the secondary lobe.

Expression under the control of Scer\GAL4^e33C leads to decreased temporal variation in mitochondria branch number and junction number in the larval lymph gland.

(Ray et al., 2021)

Expression of asrij^GD2167 under the control of Scer\GAL4^Hml.PU does not impair the ability of adult hemocytes to phagocytose bacteria. Adult flies expressing asrij^GD2167 with the Scer\GAL4^btl.PS driver do not show any significant increase in sensitivity (mortality rate) upon infection with either Bacillus subtilis or Escherichia coli, a slight increase in susceptibility with the Scer\GAL4^Hml.PU driver, moderately reduced survival rate upon B.subtilis infection is observed with the Scer\GAL4^e33C driver. The adult lifespan without any bacterial infection is not compromised by either Scer\GAL4^btl.PS- or Scer\GAL4^Hml.PU-driven expression of asrij^GD2167.

(Khadilkar et al., 2017)

Adults expressing asrij^GD2167 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development