FlyBase Allele Report: Dmel\Fur1[GD12608]

General Information

Symbol

Dmel\Fur1^GD12608

Species

D. melanogaster

Name

FlyBase ID

FBal0207057

Feature type

allele

Associated gene

Dmel\Fur1

Associated Insertion(s)

Carried in Construct

P{GD12608}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD12608}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD12608

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

mesothoracic tergum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

trichogen cell, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Adults expressing Fur1^GD12608 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in a weak flyer phenotype.

(Schnorrer et al., 2010)

Wings expressing Fur1^GD12608 under the control of Scer\GAL4^Bx-MS1096 appear normal.

(Künnapuu et al., 2009)

Expression under the control of Scer\GAL4^pnr-MD237 results in a colour difference between the central Scer\GAL4^pnr-MD237 expression domain of the notum and the surrounding lateral region in 40-50% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in bristle morphology defects on the notum in 40-50% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in the absence of 50-60% of the Scer\GAL4^pnr-MD237-expressing area of the notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

12608

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Fur1^GD12608, Scer\GAL4^path-c135 is a non-suppressor of embryonic/larval proventriculus outer layer phenotype of Pgant4^GD870, Scer\GAL4^path-c135

(Zhang et al., 2014)

Fur1^GD12608, Scer\GAL4^path-c135 is a non-suppressor of secretory granule phenotype of Pgant4^GD870, Scer\GAL4^path-c135

(Zhang et al., 2014)

Fur1^GD12608, Scer\GAL4^path-c135 is a non-suppressor of embryonic/larval proventriculus outer layer phenotype of Pgant4^RNAi.UAS.WIZ, Scer\GAL4^path-c135

(Zhang et al., 2014)

Fur1^GD12608, Scer\GAL4^path-c135 is a non-suppressor of secretory granule phenotype of Pgant4^RNAi.UAS.WIZ, Scer\GAL4^path-c135

(Zhang et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Fur1^GD12608 in PR cells via Scer\GAL4^c135 does not rescue the aberrant secretory apparatus structure and defective secretion seen in the PR cells of the proventriculus of pgant4^GD870- or pgant4^{dsRNA.Scer\UAS.WIZ}-expressing larvae.

(Zhang et al., 2014)

Wings expressing both Fur1^GD12608 and Fur2^VDRC.cUa under the control of Scer\GAL4^Bx-MS1096 appear normal.

(Künnapuu et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v22853

w¹¹¹⁸; P{GD12608}v22853

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

12608

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Fur1^GD12608

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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