FB2024_03 , released June 25, 2024
Allele: Dmel\hyxEY06898
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General Information
Symbol
Dmel\hyxEY06898
Species
D. melanogaster
Name
FlyBase ID
FBal0162506
Feature type
allele
Associated gene
Dmel\hyx
Associated Insertion(s)
P{EPgy2}hyxEY06898
Carried in Construct
Also Known As
hyxEY6898
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mosimann et al., 2009)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}hyxEY06898
Cytology
Description

P{EPgy2} insertion in the 5'UTR of hyx.

(Mosimann et al., 2006)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of cells expressing particular neuropeptide markers in the ap cell cluster of the NB5-6T lineage is changed relative to controls (number of eya expressing cells is increased, no. of FMRFa or Nplp1 positive cells is decreased) in hyx2/hyxEY06898 transheterozygous embryos.

      (Bahrampour and Thor, 2016)

      hyxEY06898 mutants can survive to pharate adult stages when Scer\GAL4Act5C.PI drives expression from the P{EPgy2} element. The legs of these animals have severe defects, with shortened and twisted segments.

      Flies with hyxEY06898 mutant clones in their adult tissue, generated using the Minute technique, show notches in the wing, ectopic wing vein material, deformed legs and deformed eyes. Flies with hyxEY06898 clones in the notum lack thoracic dorsal macrochaetae.

      (Mosimann et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      hyxEY06898 has abnormal starvation stress response | dominant phenotype, non-enhanceable by orb2BG02373

      (Zhang et al., 2010)
      NOT suppressed by
      Statement
      Reference

      hyxEY06898 has abnormal starvation stress response | dominant phenotype, non-suppressible by orb2BG02373

      (Zhang et al., 2010)
      Enhancer of
      Statement
      Reference

      hyxEY06898 is an enhancer of visible | adult stage phenotype of Lsi, atmsrK509

      (Zhang et al., 2010)
      NOT Enhancer of
      Statement
      Reference

      hyxEY06898 is a non-enhancer of abnormal starvation stress response | dominant phenotype of orb2BG02373

      (Zhang et al., 2010)
      Suppressor of
      Statement
      Reference

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of L5

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of Lr

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of L2

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of Lsi

      (Zhang et al., 2010)

      Scer\GAL4Act5C.PU/hyxEY06898 is a suppressor of abnormal starvation stress response | dominant phenotype of orb2BG02373

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of L1

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of visible | dominant | adult stage phenotype of L4

      (Zhang et al., 2010)
      NOT Suppressor of
      Statement
      Reference

      hyxEY06898 is a non-suppressor of abnormal starvation stress response | dominant phenotype of orb2BG02373

      (Zhang et al., 2010)
      Other
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      hyxEY06898 is an enhancer of eye phenotype of Lsi, atmsrK509

      (Zhang et al., 2010)
      NOT Enhancer of
      Statement
      Reference

      hyxEY06898/orb2BG02373 is a non-enhancer of eye disc | third instar larval stage phenotype of Lsi

      (Zhang et al., 2010)

      hyxEY06898 is a non-enhancer of eye disc | third instar larval stage phenotype of Lsi

      (Zhang et al., 2010)
      Suppressor of
      Statement
      Reference

      hyxEY06898 is a suppressor of eye phenotype of Lr

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of eye phenotype of L2

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of eye | ventral phenotype of Lsi

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of eye phenotype of L1

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of eye phenotype of L4

      (Zhang et al., 2010)

      hyxEY06898 is a suppressor of eye phenotype of L5

      (Zhang et al., 2010)
      NOT Suppressor of
      Statement
      Reference

      hyxEY06898/orb2BG02373 is a non-suppressor of eye disc | third instar larval stage phenotype of Lsi

      (Zhang et al., 2010)

      hyxEY06898 is a non-suppressor of eye disc | third instar larval stage phenotype of Lsi

      (Zhang et al., 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      hyxEY06898 is partially rescued by Scer\GAL4Act5C.PU, hyxEY06898

      (Zhang et al., 2010)
      Partially rescues

      Scer\GAL4Act5C.PU, hyxEY06898 partially rescues hyxEY06898

      (Zhang et al., 2010)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG11990EY06898
      hyx3
      (Bahrampour and Thor, 2016)
      hyxEY06898
      hyxEY6898
      (Zhang et al., 2010, Mosimann et al., 2009, Mosimann et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)