FlyBase Allele Report: Dmel\L[si]

General Information

Symbol

Dmel\L^si

Species

D. melanogaster

Name

sinuate

FlyBase ID

FBal0005898

Feature type

allele

Associated gene

Dmel\L

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | dominant | third instar larval stage

(Zhang et al., 2010)

viable

(Chern and Choi, 2002)

visible

visible | adult stage | dominant

(Zhang et al., 2010)

visible | dominant

(Son and Choi, 2020, Chern and Choi, 2002)

Phenotype Manifest In

eye

(Son and Choi, 2020, Chern and Choi, 2002)

eye | ventral

(Zhang et al., 2010)

eye disc | third instar larval stage

(Zhang et al., 2010)

Detailed Description

Statement

Reference

Heterozygotes have a nick near the anterior midline of one or both eyes in 70% of cases and the overall size of the eye is reduced. Homozygotes show a preferential loss of the ventral eye with complete penetrance.

(Chern and Choi, 2002)

Eyes of heterozygote flat, smooth, nearly full size, with sinuate margin; overlaps wild type only slightly. Eyes of homozygotes smaller with flat or concave contour, smooth surface, and sinuate lower margin. RK3.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

L^si, atms^rK509 has visible | adult stage phenotype, enhanceable by hyx^EY06898

(Zhang et al., 2010)

L^si has visible | dominant phenotype, enhanceable by N^264-47/N[+]

(Chern and Choi, 2002)

Suppressed by

Statement

Reference

L^si has visible | dominant | adult stage phenotype, suppressible by hyx^EY06898

(Zhang et al., 2010)

L^si has visible | dominant | adult stage phenotype, suppressible by orb2^BG02373

(Zhang et al., 2010)

Other

Statement

Reference

L^si, atms^rK509 has visible | adult stage phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has increased occurrence of cell division | third instar larval stage phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb^dec has visible | adult stage phenotype

(Zhang et al., 2010)

L^si, atms^NP5451, hyx^EY06898 has visible | adult stage phenotype

(Zhang et al., 2010)

CG9899^NP5197, L^si, hyx^EY06898 has visible | adult stage phenotype

(Zhang et al., 2010)

Atu^s1938, L^si, hyx^EY06898 has visible | adult stage phenotype

(Zhang et al., 2010)

L^si, arm^G0192, hyx^EY06898 has visible | adult stage phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has visible | adult stage phenotype

(Zhang et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

L^si, atms^rK509 has eye phenotype, enhanceable by hyx^EY06898

(Zhang et al., 2010)

L^si has eye phenotype, enhanceable by N^264-47/N[+]

(Chern and Choi, 2002)

NOT Enhanced by

Statement

Reference

L^si has eye disc | third instar larval stage phenotype, non-enhanceable by hyx^EY06898/orb2^BG02373

(Zhang et al., 2010)

L^si has eye disc | third instar larval stage phenotype, non-enhanceable by hyx^EY06898

(Zhang et al., 2010)

Suppressed by

Statement

Reference

L^si has eye | ventral phenotype, suppressible by hyx^EY06898

(Zhang et al., 2010)

L^si has eye | ventral phenotype, suppressible by orb2^BG02373

(Zhang et al., 2010)

NOT suppressed by

Statement

Reference

L^si has eye disc | third instar larval stage phenotype, non-suppressible by hyx^EY06898/orb2^BG02373

(Zhang et al., 2010)

L^si has eye disc | third instar larval stage phenotype, non-suppressible by hyx^EY06898

(Zhang et al., 2010)

Suppressor of

Statement

Reference

L^si is a suppressor of eye disc phenotype of N^ICN.UAS, Scer\GAL4^dpp.blk1

(Chern and Choi, 2002)

Other

Statement

Reference

L^si, atms^rK509 has eye phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has ommatidium | adult stage phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb^dec has eye phenotype

(Zhang et al., 2010)

L^si, atms^NP5451, hyx^EY06898 has eye phenotype

(Zhang et al., 2010)

CG9899^NP5197, L^si, hyx^EY06898 has eye phenotype

(Zhang et al., 2010)

Atu^s1938, L^si, hyx^EY06898 has eye phenotype

(Zhang et al., 2010)

L^si, arm^G0192, hyx^EY06898 has eye phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has eye phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has interommatidial bristle phenotype

(Zhang et al., 2010)

L^si, hyx^EY06898, orb2^BG02373 has eye disc | third instar larval stage phenotype

(Zhang et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

L^si strongly suppresses the overgrowth of the ventral part of the eye disc in animals expressing N^ICN.Scer\UAS under the control of Scer\GAL4^dpp.blk1, but has little effect on dorsal outgrowth of the eye discs in these animals. The severity of the eye phenotype of L^si/+ flies is enhanced if they are also heterozygous for N^264-47.

(Chern and Choi, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

L^si/L[+] is rescued by L^GLV21080/Scer\GAL4^ey.PU

(Son and Choi, 2020)

Comments

Expression of L^GLV21080 under the control of Scer\GAL4^ey.PU strongly suppresses the L^si/+ eye phenotype.

(Son and Choi, 2020)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

324

L^si

Notes on Origin

Discoverer

Morgan, 1932.

Comments

Phenotypic series: L¹ > L^si > L^r.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

L^si

(Son and Choi, 2020, Singh et al., 2011, Zhang et al., 2010, Singh et al., 2006)

Name Synonyms

sinuate

Secondary FlyBase IDs

References (6)

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