FlyBase Allele Report: Dmel\LIMK1[EY08757]

General Information

Symbol

Dmel\LIMK1^EY08757

Species

D. melanogaster

Name

FlyBase ID

FBal0160256

Feature type

allele

Associated gene

Dmel\LIMK1

Associated Insertion(s)

P{EPgy2}LIMK1^EY08757

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}LIMK1^EY08757

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:12,591,904..12,591,904 [-]

(Sass and Ostrow, 2014, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates alcohol use disorder

modeled by RhoGAP18B¹

(Ojelade et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage

(Miller et al., 2011)

fertile

(Gene Disruption Project members, 2001-)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

(Miller et al., 2011)

Detailed Description

Statement

Reference

LIMK1^EY08757/LIMK1^EY08757 mutant adults show no change in their sensitivity to ethanol-induced sedation (measured by a loss of righting assay) compared to wild-type.

(Ojelade et al., 2015)

Homozygous LIMK1^EY08757 mutants exhibit ISNb defasciculation defects in 51% of hemisegments.

(Miller et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

LIMK1^EY08757 has abnormal neuroanatomy | embryonic stage phenotype, enhanceable by frac^Δ1/frac[+]

(Miller et al., 2011)

Enhancer of

Statement

Reference

LIMK1^EY08757/LIMK1[+] is an enhancer of abnormal neuroanatomy | embryonic stage phenotype of frac^Δ1

(Miller et al., 2011)

Suppressor of

Statement

Reference

LIMK1^EY08757/LIMK1^EY08757 is a suppressor of chemical resistant | adult stage phenotype of RhoGAP18B¹

(Ojelade et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

LIMK1^EY08757 has larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype, enhanceable by frac^Δ1/frac[+]

(Miller et al., 2011)

Enhancer of

Statement

Reference

LIMK1^EY08757/LIMK1[+] is an enhancer of larval intersegmental nerve branch ISNb of A1-7 | embryonic stage phenotype of frac^Δ1

(Miller et al., 2011)

NOT Enhancer of

Statement

Reference

LIMK1^EY08757 is a non-enhancer of wing phenotype of Pkn^k06808

(Sass and Ostrow, 2014)

NOT Suppressor of

Statement

Reference

LIMK1^EY08757 is a non-suppressor of wing phenotype of Pkn^k06808

(Sass and Ostrow, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The increased resistance to ethanol-induced sedation observed in RhoGAP18B¹/RhoGAP18B¹ adults can be suppressed by combination with LIMK1^EY08757/LIMK1^EY08757.

(Ojelade et al., 2015)

The ISNb of LIMK1^EY08757; frac^Δ1 double heterozygous mutant embryos is defasciculated and has ectopic projections. These double mutants display an increase in mis-projections relative to either heterozygote alone.

(Miller et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17491

y¹ w^67c23 P{EPgy2}LIMK1^EY08757

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

LIMK1^EY08757

(Ojelade et al., 2015, White-Grindley et al., 2014, Miller et al., 2011)

LIMK^EY08757

(Sass and Ostrow, 2014)

LimK^MT

(White-Grindley et al., 2014)

Limk^EY

(Ojelade et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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