FlyBase Allele Report: Dmel\mip130[1-36]

General Information

Symbol

Dmel\mip130^1-36

Species

D. melanogaster

Name

FlyBase ID

FBal0158949

Feature type

allele

Associated gene

Dmel\mip130

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Beall et al., 2004)

Mutagen

I-CreI

(Beall et al., 2004)

gene targeting by homologous recombination

(Beall et al., 2004)

Progenitor genotype

mip130^1-723+1-36

(Beall et al., 2004)

Cytology

Description

Mutation in mip130 resulting in a new BamHI site 45 nucleotides from the start codon. The mutant allele is expected to produce a 36 amino acid protein, of which the last 21 amino acids are not mip130 sequence.

(Beall et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile

(Beall et al., 2004)

viable

(Beall et al., 2004)

Phenotype Manifest In

egg chorion

(Beall et al., 2004)

Detailed Description

Statement

Reference

Embryos derived from females carrying homozygous mip130^1-36 germline clones crossed to wild type males are able to hatch at a similar rate to wild type.

(Lewis et al., 2012)

Mutant animals are smaller than wild-type and are unhealthy. Mutant females produce eggs that are flaccid and have thin eggshells. Very few larvae hatch.

(Beall et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

mip130^1-36 has female semi-sterile phenotype, non-enhanceable by Myb^MH107

(Beall et al., 2004)

NOT suppressed by

Statement

Reference

mip130^1-36 has female semi-sterile phenotype, non-suppressible by Myb^MH107

(Beall et al., 2004)

Suppressor of

Statement

Reference

(Lewis et al., 2012)

mip130^1-36 is a suppressor of visible | somatic clone | adult stage phenotype of lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of visible | somatic clone | adult stage phenotype of Myb^MH107, lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of lethal | recessive phenotype of Myb^MH107

(Beall et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

mip130^1-36 is a suppressor of eye | somatic clone phenotype of lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of rhabdomere | somatic clone | adult stage phenotype of lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of ommatidium | somatic clone | adult stage phenotype of lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of eye | somatic clone phenotype of Myb^MH107, lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of ommatidium | somatic clone | adult stage phenotype of Myb^MH107, lin-52⁹³

(Lewis et al., 2012)

mip130^1-36 is a suppressor of rhabdomere | somatic clone | adult stage phenotype of Myb^MH107, lin-52⁹³

(Lewis et al., 2012)

(Lewis et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous mip130^1-36 suppresses the eye phenotypes seen in lin-52⁹³ mutant eye clones. The mutant tissue appears completely normal.

Homozygous mip130^1-36 suppresses the eye phenotypes seen in Myb^MH107, lin-52⁹³ double mutant clones. The resulting triple mutant eyes appear completely normal.

Approximately 29% of embryos derived from females carrying homozygous lin-52⁹³ mip130^1-36 double mutant germline clones crossed to wild type males are able to hatch, a partial suppression of the phenotype seen when females are maternally mutant for lin-52⁹³ alone.

(Lewis et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

83144

mip130^1-36 w^* P{neoFRT}18A/FM7c

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

mip130^1-36

(Debruhl et al., 2013, Lewis et al., 2012, Scaria et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close