FlyBase Allele Report: Dmel\lola[ORE119]

General Information

Symbol

Dmel\lola^ORE119

Species

D. melanogaster

Name

FlyBase ID

FBal0151748

Feature type

allele

Associated gene

Dmel\lola

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Horiuchi et al., 2003)

Progenitor genotype

Cytology

Description

Nucleotide substitution: T37988C. Amino acid replacement: P712L.

(Horiuchi et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:10,505,302..10,505,302 [-]

Nucleotide change:

C10505302T

Reported nucleotide change:

C37988T

Amino acid change:

P712L | lola-PB; P712L | lola-PC

Reported amino acid change:

P712L|lola-PB

Comment:

P712 is replaced by L in the C5-8,V23 isoforms.

(Horiuchi et al., 2003, Horiuchi et al., 2003)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Horiuchi et al., 2003)

abnormal neuroanatomy | somatic clone

(Spletter et al., 2007)

lethal (with Df(2R)BSC595)

(Tripathy et al., 2014)

lethal (with Df(2R)stan2)

(Horiuchi et al., 2003)

lethal | recessive

(Horiuchi et al., 2003)

partially lethal (with lola^c46)

(Horiuchi et al., 2003)

viable (with lola^ORC4)

(Horiuchi et al., 2003)

viable (with lola^ORE50)

(Horiuchi et al., 2003)

viable (with lola^ORE120)

(Horiuchi et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

No gonad defects are observed in homozygous lola^ORE119 mutant embryos.

(Tripathy et al., 2014)

lola^ORE119 MARCM clones show normal antero-dorsal projection neuron (PN) targeting, but lateral and ventral PNs show a loss of targeting.

(Spletter et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

lola^ORE119 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

lola^ORE119 is an enhancer of wing margin phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Kwon et al., 2013)

lola[+]/lola^ORE119 is an enhancer of wing margin phenotype of ct^53d

(Krupp et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The wing nicking phenotype caused by expression of dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 is enhanced if the flies are also carrying lola^ORE119.

(Kwon et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

lola^ORC4

(Horiuchi et al., 2003)

lola^ORE50

(Horiuchi et al., 2003)

lola^ORE120

(Horiuchi et al., 2003)

lola^c46

(Horiuchi et al., 2003)

Fails to complement

lola^5D2

(Horiuchi et al., 2003)

Not rescued by

lola^ORE119 is not rescued by lola^L.UAS/Scer\GAL4^unspecified

(Spletter et al., 2007)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28284

w^*; lola^ORE119/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lola^ORE119

(Tripathy et al., 2014, Davies et al., 2013, Kwon et al., 2013)

lola^ore119

(Spletter et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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