FB2024_03 , released June 25, 2024
Allele: Dmel\timper3'UTR.tim.Tag:HA
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General Information
Symbol
Dmel\timper3'UTR.tim.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0143160
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
P{tim-tim.HA.per3'UTR}
Key Links
Transgenic product class
wild_type
(Rutila et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Rutila et al., 1998)
Mutagen
in vitro construct
(Beaver et al., 2002, Rutila et al., 1998)
Progenitor genotype
Carried in construct
P{tim-tim.HA.per3'UTR}
Cytology
Description

Approximately 4.5 kb of genomic upstream tim DNA, including the first intron, is fused to the tim cDNA. The 3' end of this cDNA is fused in frame to Tag:HA, followed by the 3' UTR of per.

(Rutila et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
tim
Encoded product / tool
tim
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      tim01/tim01; timper3'UTR.tim.T:Ivir\HA1/timper3'UTR.tim.T:Ivir\HA1 flies show a low percentage (7%) rhythmicity when kep in constant light.

      (Peschel et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      timper3'UTR.tim.Tag:HA is an enhancer of abnormal locomotor rhythm phenotype of jetc, timls/tim01

      (Peschel et al., 2006)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      timls/tim01, jetc (Veela/tim01) flies show 22% anomalous rhythmicity when kept in constant light, while flies of the same genotype that additionally carry one copy of the timper3'UTR.tim.T:Ivir\HA1 transgene (which has the same coding sequence as the timls allele) show 63% rhythmicity in constant light.

      (Peschel et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      timper3'UTR.tim.Tag:HA rescues tim03/tim01

      (Beaver et al., 2002)
      Comments

      timper3'UTR.tim.T:Ivir\HA1 suppresses the reduced fertility of tim01/tim03 flies, and the reduction of sperm numbers in the seminal vesicles of two day old tim01/tim03 males.

      (Beaver et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Rutila.

      (Beaver et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      timper3'UTR.tim.T:Ivir\HA1
      timper3'UTR.tim.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (3)