FB2024_03 , released June 25, 2024
Allele: Dmel\jetc
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General Information
Symbol
Dmel\jetc
Species
D. melanogaster
Name
common
FlyBase ID
FBal0195806
Feature type
allele
Associated gene
Dmel\jet
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Peschel et al., 2006)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T?A.

(Koh et al., 2006)

Amino acid replacement: F?I.

(Koh et al., 2006)

Amino acid replacement: F209I.

(Koh et al., 2006)

The F209I substitution is within a conserved 'LRR' domain.

(Koh et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:4,949,049..4,949,049 [-]
Nucleotide change:

T4949049A

Reported nucleotide change:

T?A

Amino acid change:

F209I | jet-PA; F209I | jet-PB

Reported amino acid change:

F209I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Koh et al., 2006, Koh et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      jetc mutants can be trained to light:dark LD cycles, but take longer to be re-entrained to a new schedule than wild-type flies. The behaviour of these mutant flies within LD and constant darkness is not different to wild-type flies.

      While few wild-type flies show rhythmic behaviour in constant light conditions, jetc, jetc/jetr, jetc/Df(2L)Exel8012 and jetc/Df(2L)Exel7021 mutants all show rhythmic behaviour under these conditions. Additionally, jetr mutants show reduced responses to light pulses compared to wild-type flies.

      (Koh et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      jetc/jet[+], timls has abnormal locomotor rhythm phenotype, enhanceable by cry[+]/cryb

      (Peschel et al., 2006)

      jetc, timls/tim[+] has abnormal locomotor rhythm phenotype, enhanceable by cry[+]/cryb

      (Peschel et al., 2006)

      jetc, timls/tim01 has abnormal locomotor rhythm phenotype, enhanceable by timper3'UTR.tim.Tag:HA

      (Peschel et al., 2006)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      timls, jetc double mutants are referred to as "Veela" flies. 85% of timls/timls, jetc/jetc (Veela/Veela) double mutants show anomalous rhythmicity when kept in constant light, while 31% of timls/+, jetc/+ (Veela/+) double heterozygotes show this phenotype. Flies of this genotype behave normally when kept in constant darkness.

      timls/+, jetc/+ (Veela/+); cryb/+ flies exhibit robust rhythmicity in constant light, this phenotype is stronger than in timls/+, jetc/+ (Veela/+) flies and is not seen in cryb/+ flies.

      tims, jetc show behavioral arrhythmicity in constant light conditions, like wild-type flies.

      timls/tim01, jetc (Veela/tim01) flies show 22% anomalous rhythmicity when kept in constant light, while flies of the same genotype that additionally carry one copy of the timper3'UTR.tim.T:Ivir\HA1 transgene (which has the same coding sequence as the timls allele) show 63% rhythmicity in constant light.

      (Peschel et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      jetc is partially rescued by Scer\GAL4tim.PE/jetUAS.cKa

      (Koh et al., 2006)

      jetc is partially rescued by jetUAS.cKa/Scer\GAL4cry.PU

      (Koh et al., 2006)
      Comments

      Expression of the jetScer\UAS.cKa transgene, under the control of either Scer\GAL4cry.PU or Scer\GAL4tim.PE, partially rescues the reduced light response phenotype of jetc mutants.

      (Koh et al., 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      jetc
      (Lamba et al., 2014, Chen et al., 2011, Koh et al., 2006, Koh et al., 2006, Peschel et al., 2006)
      Name Synonyms
      common
      (Van Gelder, 2006)
      Secondary FlyBase IDs
        References (6)