FB2024_03 , released June 25, 2024
Allele: Dmel\timls
Open Close
General Information
Symbol
Dmel\timls
Species
D. melanogaster
Name
FlyBase ID
FBal0211083
Feature type
allele
Associated gene
Dmel\tim
Associated Insertion(s)
Carried in Construct
Also Known As
ls-tim
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Peschel et al., 2006)
Progenitor genotype
Cytology
Description

The timls allele encodes both the "long" and "short" forms of tim protein.

(Peschel et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      timls flies kept in constant light conditions show locomotor arrhythmicity, as do wild-type flies.

      tims flies show a larger phase response to light pulses than timls flies.

      (Sandrelli et al., 2007)

      timls females show reproductive arrest more readily than tims females.

      (Tauber et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      jetc/jet[+], timls has abnormal locomotor rhythm phenotype, enhanceable by cry[+]/cryb

      (Peschel et al., 2006)

      jetc, timls/tim[+] has abnormal locomotor rhythm phenotype, enhanceable by cry[+]/cryb

      (Peschel et al., 2006)

      jetc, timls/tim01 has abnormal locomotor rhythm phenotype, enhanceable by timper3'UTR.tim.Tag:HA

      (Peschel et al., 2006)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      timls, jetc double mutants are referred to as "Veela" flies. 85% of timls/timls, jetc/jetc (Veela/Veela) double mutants show anomalous rhythmicity when kept in constant light, while 31% of timls/+, jetc/+ (Veela/+) double heterozygotes show this phenotype. Flies of this genotype behave normally when kept in constant darkness.

      timls/+, jetc/+ (Veela/+); cryb/+ flies exhibit robust rhythmicity in constant light, this phenotype is stronger than in timls/+, jetc/+ (Veela/+) flies and is not seen in cryb/+ flies.

      timls/tim01, jetc (Veela/tim01) flies show 22% anomalous rhythmicity when kept in constant light, while flies of the same genotype that additionally carry one copy of the timper3'UTR.tim.T:Ivir\HA1 transgene (which has the same coding sequence as the timls allele) show 63% rhythmicity in constant light.

      (Peschel et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)