FlyBase Allele Report: Dmel\trol[p4]

General Information

Symbol

Dmel\trol^p4

Species

D. melanogaster

Name

FlyBase ID

FBal0143153

Feature type

allele

Associated gene

Dmel\trol

Associated Insertion(s)

Carried in Construct

Also Known As

trol⁴

Key Links

Allele class

Mutagen

diepoxybutane

Nature of the Allele

Allele class

Mutagen

diepoxybutane

(Park et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | larval stage

(Park et al., 2003, Park et al., 2001)

lethal

(Park et al., 2001)

viable (with trol¹³)

(Park et al., 2001)

Phenotype Manifest In

larval brain & neuroblast

(Park et al., 2001)

neuroblast

(Park et al., 2003)

Detailed Description

Statement

Reference

trol^p4 homozygous first instar larvae show reduced proliferation of neuroblasts.

(Park et al., 2003)

Hemizygous brains show a bimodal distribution of larval neuroblast proliferation; 43% show proliferation within control values, while proliferation is decreased in 57% of cases.

(Park et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

trol^p4 has decreased occurrence of cell division | larval stage phenotype, enhanceable by bnl⁰⁶⁹¹⁶/bnl[+]

(Park et al., 2003)

trol^p4 has decreased occurrence of cell division | larval stage phenotype, enhanceable by btl^LG19/btl[+]

(Park et al., 2003)

trol^p4 has decreased occurrence of cell division | larval stage phenotype, enhanceable by ttv[+]/ttv^00681b

(Park et al., 2003)

trol^p4 has decreased occurrence of cell division | larval stage phenotype, enhanceable by eve³/eve[+]

(Park et al., 2001)

NOT Enhanced by

Statement

Reference

trol^p4 has decreased occurrence of cell division | larval stage phenotype, non-enhanceable by htl^AB42/htl[+]

(Park et al., 2003)

Suppressed by

Statement

Reference

trol^p4 has decreased occurrence of cell division | larval stage phenotype, suppressible by CycE^hs.PR

(Park et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

trol^p4 has neuroblast | larval stage phenotype, enhanceable by bnl⁰⁶⁹¹⁶/bnl[+]

(Park et al., 2003)

trol^p4 has neuroblast | larval stage phenotype, enhanceable by btl^LG19/btl[+]

(Park et al., 2003)

trol^p4 has larval neuroblast | larval stage phenotype, enhanceable by ttv[+]/ttv^00681b

(Park et al., 2003)

trol^p4 has larval brain & neuroblast phenotype, enhanceable by eve³/eve[+]

(Park et al., 2001)

NOT Enhanced by

Statement

Reference

trol^p4 has neuroblast | larval stage phenotype, non-enhanceable by htl^AB42/htl[+]

(Park et al., 2003)

Suppressed by

Statement

Reference

trol^p4 has neuroblast | larval stage phenotype, suppressible by CycE^hs.PR

(Park et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Reduction in neuroblast proliferation in trol^p4 homozygous larvae is suppressed by heat shock of CycE^hs.PR animals. Reduction in S phase larval neuroblasts per brain lobe in trol^p4 homozygotes is enhanced by heterozygosity for bnl⁰⁶⁹¹⁶ or btl^LG19 but not htl^AB42. Of ttv^00681b/+; trol^p4/trol^p4 larvae, 29% show increased numbers of S phase neuroblasts per brain lobe and while 5% show decreased numbers.

(Park et al., 2003)

The proliferation defect seen in trol^p4 animals is enhanced by one copy of eve³; 100% of animals show defective proliferation.

(Park et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

trol⁴

(Grigorian et al., 2013, Park et al., 2003, Park et al., 2001)

trol^p4

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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