FlyBase Allele Report: Dmel\Ptp52F[8.10.3]

General Information

Symbol

Dmel\Ptp52F^8.10.3

Species

D. melanogaster

Name

FlyBase ID

FBal0128126

Feature type

allele

Associated gene

Dmel\Ptp52F

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Schindelholz et al., 2001)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y1348N.

(Schindelholz et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:16,171,505..16,171,505 [-]

Nucleotide change:

T16171505A

Amino acid change:

Y1347N | Ptp52F-PB

Reported amino acid change:

Y1348N

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement (Figure 1 sequence).

(Schindelholz et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Ptp52F^8.10.3 heterozygotes and, more severely, Ptp52F^8.10.3/Ptp52F^18.3 transheterozygotes exhibit a significant decrease in the apoptosis levels in gastric caecum cells, and delays in both the histolysis of larval midgut and the removal of the gastric caeca during metamorphosis, as compared to controls.

(Santhanam et al., 2014)

Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a range of phenotypes in the SNa branch of the segmental nerve. Additional branches are seen at random position, either the posterior of anterior branch is missing, or occasionally in Ptp52F^8.10.3/Df(2R)Jp4 the SNa stalls near the bifurcation point. Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a weak phenotype in the ISNb nerve branch. ISNb occasionally stalls in the VLM field. Homozygous mutants, and hemizygous mutants (over Df(2R)Jp4 or Df(2R)Jp8) show a range of phenotypes in the Intersegmental nerve (ISN). ISNs sometimes terminate at the second branchpoint, and occasionally ISN appear to reach the terminal arbor position, but are thin or bifurcated.

(Schindelholz et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Ptp52F^8.10.3 has larval intersegmental nerve phenotype, enhanceable by Ptp10D¹

(Schindelholz et al., 2001)

Ptp52F^8.10.3 has larval VO2 motor neuron phenotype, enhanceable by Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 has larval VL3/4 motor neuron phenotype, enhanceable by Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 has larval VO1 motor neuron phenotype, enhanceable by Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 has larval RP5 motor neuron phenotype, enhanceable by Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 has larval intersegmental nerve phenotype, enhanceable by Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Enhancer of

Statement

Reference

Ptp52F^8.10.3 is an enhancer of larval intersegmental nerve phenotype of Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 is an enhancer of larval VO2 motor neuron phenotype of Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 is an enhancer of larval VL3/4 motor neuron phenotype of Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 is an enhancer of larval VO1 motor neuron phenotype of Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Ptp52F^8.10.3 is an enhancer of larval RP5 motor neuron phenotype of Ptp69D¹/Df(3L)8ex25

(Schindelholz et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of Ptp10D¹ enhances the ISNb phenotype seen in Ptp52F^8.10.3 homozygotes alone. A bypass phenotype is also occasionally seen. The addition of Ptp69D¹/Df(3L)8ex25 enhances the SNa phenotype seen in Ptp52F^8.10.3 homozygotes alone. The addition of Ptp52F^18.3 or Ptp52F^8.10.3 to Ptp69D¹/Df(3L)8ex25 mutant embryos strongly enhances the ISNb phenotype seen. The addition of Ptp10D¹ strongly enhances the ISN phenotypers seen in Ptp52F^18.3 mutants alone. The addition of Ptp52F^8.10.3 to Ptp69D¹/Df(3L)8ex25 mutant embryos strongly enhances the ISN phenotype seen.

(Schindelholz et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6589

Ptp52F^8.10.3/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ptp52F^8.10.3

(Santhanam et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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