FB2024_03 , released June 25, 2024
Allele: Dmel\dom3
Open Close
General Information
Symbol
Dmel\dom3
Species
D. melanogaster
Name
FlyBase ID
FBal0123003
Feature type
allele
Associated gene
Dmel\dom
Associated Insertion(s)
P{lacW-Δ3.R}dom3
Carried in Construct
Also Known As
dom3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Ruhf et al., 2001)
Progenitor genotype
domk08108
(Ruhf et al., 2001)
Associated Insertion(s)
P{lacW-Δ3.R}dom3
Cytology
Description

Internal deletion of P{lacW} of P{lacW}domk08108 progenitor, inactivating the w+mC allele.

(Ruhf et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      98% of flies expressing domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 in a dom3/+ background show wing nicking.

      (Kwon et al., 2013)

      dom3 homozygous female germ-line stem cells are lost from their stem cell niche at the same rate as wild-type female germ-line stem cells. However, 94% of dom3 homozygous clone follicle stem cells are lost from their niche within 17 days, compared to only 37.5% of cells in wild-type control clones. This is not accompanied by any increase in in apoptosis of these cells.

      (Xi and Xie, 2005)

      Lethality acts in the early pupal stages. Lymph glands are overgrown, more or less blackened, imaginal discs are reduced or normal, brain apparently normal. Females with germline clones do not lay eggs.

      (Ruhf et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dom3
      (Prozzillo et al., 2021)
      dom3
      (Messina et al., 2014)
      dom3
      (Kahsai and Cook, 2018, Kwon et al., 2013, Christensen et al., 2009.6.15, Xi and Xie, 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)