FlyBase Allele Report: Dmel\dom[9]

General Information

Symbol

Dmel\dom⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0123000

Feature type

allele

Associated gene

Dmel\dom

Associated Insertion(s)

P{lacW-Δ9.R}dom⁹

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Ruhf et al., 2001)

Mutagen

Delta2-3 transposase

(Ruhf et al., 2001)

Progenitor genotype

dom^k08108

(Ruhf et al., 2001)

Associated Insertion(s)

P{lacW-Δ9.R}dom⁹

Cytology

Description

Internal deletion of P{lacW} of P{lacW}dom^k08108 progenitor, inactivating the w^+mC allele.

(Ruhf et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing

(Ruhf et al., 2001)

wing margin (with dom^RNAi.Sym.UAS), with Scer\GAL4^bbg-C96

(Kwon et al., 2013)

Detailed Description

Statement

Reference

72% of flies expressing dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96 in a dom⁹/+ background show wing nicking.

(Kwon et al., 2013)

Lethality acts during pupal and adult stages. There are no clear larval defects. Surviving adults are female-sterile (ovaries apparently normal, eggs are laid) but male fertile. Wings are often abnormal with crumpled, held-out phenotypes. Somatic clones can be induced though they show reduced cell number compared to wild type counterparts. Females with germline clones lay a few eggs which show a broad range of defects and are inviable.

(Ruhf et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dom⁹/dom⁷ has partially lethal phenotype, suppressible | partially by Hsap\SRCAP^{Chi.Tag:polyHis}

(Eissenberg et al., 2005)

dom⁹/dom⁷ has female sterile phenotype, suppressible by Hsap\SRCAP^{Chi.Tag:polyHis}