FlyBase Allele Report: Dmel\Catsup[26]

General Information

Symbol

Dmel\Catsup²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0101765

Feature type

allele

Associated gene

Dmel\Catsup

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Stathakis et al., 1999)

Progenitor genotype

Catsup^k05402

(Stathakis et al., 1999)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in an approximately 600bp deletion of genomic DNA.

(Stathakis et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal grooming behavior | adult stage | dominant

(Wang et al., 2011)

chemical resistant | adult stage | dominant

(Wang et al., 2011)

increased rate of movement | adult stage | dominant

(Wang et al., 2011)

lethal (with Catsup⁴⁷)

(Groth et al., 2013)

lethal (with Catsup⁴⁸)

(Groth et al., 2013)

Phenotype Manifest In

embryonic/larval tracheal dorsal trunk

(Hsouna et al., 2007)

embryonic/larval tracheal system

(Hsouna et al., 2007)

Detailed Description

Statement

Reference

Heterozygous adults are hyperactive (showing increased overall activity) and show increased grooming behaviour compared to wild type.

Heterozygous adults show increased resistance to reserpine compared to wild type.

(Wang et al., 2011)

Homozygous embryos show a loss of branches in the tracheal system, including gaps in the dorsal trunk. This is due to a loss of tracheal cell migration.

67% of heterozygous embryos show a tracheal lack of migration phenotype.

(Hsouna et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Catsup[+]/Catsup²⁶ is an enhancer of visible | dominant phenotype of N^264-107

(Groth et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Catsup²⁶ has embryonic/larval tracheal system phenotype, enhanceable by btl^H82Δ3/btl[+]

(Hsouna et al., 2007)

Suppressed by

Statement

Reference

Catsup²⁶ has embryonic/larval tracheal system phenotype, suppressible | partially by awd^j2A4/awd[+]

(Hsouna et al., 2007)

Catsup²⁶ has embryonic/larval tracheal system phenotype, suppressible | partially by Pu[+]/Pu^rAA17

(Hsouna et al., 2007)

Catsup²⁶ has embryonic/larval tracheal system phenotype, suppressible by Pu[+]/Pu^Z22

(Hsouna et al., 2007)

Enhancer of

Statement

Reference

Catsup[+]/Catsup²⁶ is an enhancer of wing phenotype of N^264-107

(Groth et al., 2013)

Suppressor of

Statement

Reference

Catsup[+]/Catsup²⁶ is a suppressor | partially of embryonic/larval tracheal system phenotype of Pu^rAA17

(Hsouna et al., 2007)

Catsup[+]/Catsup²⁶ is a suppressor | partially of embryonic/larval tracheal system phenotype of Pu^Z22

(Hsouna et al., 2007)

Catsup[+]/Catsup²⁶ is a suppressor of embryonic/larval tracheal system phenotype of awd^j2A4

(Hsouna et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The wing notching phenotype seen in Df(1)N-54l9/+ and N^264-107/+ flies is enhanced by heterozygosity for Catsup²⁶.

(Groth et al., 2013)

The severity and penetrance of the Catsup²⁶/+ tracheal lack of migration phenotype is enhanced by btl^H82Δ3/+.

The opposing tracheal phenotypes of awd^j2A4/+ and Catsup²⁶/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in awd^j2A4/+ Catsup²⁶/+ double heterozygous embryos.

The opposing tracheal phenotypes of Pu^rAA17/+ and Catsup²⁶/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in Pu^rAA17/+ Catsup²⁶/+ double heterozygous embryos.

The ectopic tracheal migration phenotype of Pu^Z22/+ single heterozygous embryos is partially suppressed and the lack of tracheal migration phenotype of Catsup²⁶/+ single heterozygous embryos is completely suppressed in Pu^Z22/+ Catsup²⁶/+ double heterozygous embryos.

(Hsouna et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Catsup¹²

(Stathakis et al., 1999)

Catsup¹¹

(Stathakis et al., 1999)

Catsup¹

(Stathakis et al., 1999)