FB2024_03 , released June 25, 2024
Allele: Dmel\Catsup47
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General Information
Symbol
Dmel\Catsup47
Species
D. melanogaster
Name
FlyBase ID
FBal0296094
Feature type
allele
Associated gene
Dmel\Catsup
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Groth et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: G178D.

(Groth et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,042,533..19,042,533 [+]
Nucleotide change:

G19042533A

Amino acid change:

G178D | Catsup-PA

Reported amino acid change:

G178D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Groth et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Virtually all mutant embryos hatch, but the larvae arrest at the first instar stage for 3-4 days, are akinetic and eventually die before without progressing to the second instar.

      Homozygous clones in the wing result in loss of wing margin and wing notching at the tip in less than 5% of cases.

      (Groth et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Catsup[+]/Catsup47 is an enhancer of visible | dominant phenotype of N264-107

      (Groth et al., 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Catsup[+]/Catsup47 is an enhancer of wing phenotype of N264-107

      (Groth et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing notching phenotype seen in Df(1)N-54l9/+ and N264-107/+ flies is enhanced by heterozygosity for Catsup47.

      (Groth et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Catsup26/Catsup47 is rescued by CatsupUAS.Tag:V5/Scer\GAL4da.G32

      (Groth et al., 2013)
      Comments

      Expression of CatsupScer\UAS.T:SV5\V5 under the control of Scer\GAL4da.G32 rescues the lethality of Catsup47/Catsup26 animals.

      (Groth et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Catsup47
      (Groth et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)