FB2024_03 , released June 25, 2024
Allele: Dmel\PurAA17
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General Information
Symbol
Dmel\PurAA17
Species
D. melanogaster
Name
FlyBase ID
FBal0014017
Feature type
allele
Associated gene
Dmel\Pu
Associated Insertion(s)
Carried in Construct
Also Known As
PuAA17
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mackay et al., 1985)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have ectopically migrating tracheal branches and tracheal cells. Ectopic looping of the dorsal branches is seen and the dorsal trunk is sometimes convoluted. In the most severe cases, rounded "run-away" tracheal cells are seen throughout the embryo and there is a complete loss of the tracheal network.

      84% of heterozygous embryos show ectopic tracheal migration.

      (Hsouna et al., 2007)

      Embryos have completely unpigmented and weak cuticles.

      (O'Donnell et al., 1989)

      Cuticle defects.

      (Reynolds and O'Donnell, 1987)

      Eye colour: mutant in trans with a homozygous viable Pu allele.

      (Mackay et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      PurAA17 has embryonic/larval tracheal system phenotype, enhanceable by awdj2A4/awd[+]

      (Hsouna et al., 2007)

      PurAA17 has embryonic/larval tracheal system phenotype, enhanceable by shi2

      (Hsouna et al., 2007)
      Suppressed by
      Statement
      Reference

      PurAA17 has embryonic/larval tracheal system phenotype, suppressible | partially by btlH82Δ3/btl[+]

      (Hsouna et al., 2007)

      PurAA17 has embryonic/larval tracheal system phenotype, suppressible | partially by Catsup[+]/Catsup26

      (Hsouna et al., 2007)
      Enhancer of
      Statement
      Reference

      Pu[+]/PurAA17 is an enhancer of embryonic/larval tracheal system phenotype of awdj2A4

      (Hsouna et al., 2007)

      Pu[+]/PurAA17 is an enhancer of embryonic/larval tracheal system phenotype of shi2

      (Hsouna et al., 2007)
      Suppressor of
      Statement
      Reference

      Pu[+]/PurAA17 is a suppressor | partially of embryonic/larval tracheal system phenotype of Catsup26

      (Hsouna et al., 2007)

      Pu[+]/PurAA17 is a suppressor of embryonic/larval tracheal system phenotype of btlH82Δ3

      (Hsouna et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The penetrance and severity of the ectopic tracheal migration phenotype is increased in PurAA17 awdj2A4 double heterozygous embryos compared to either single heterozygote.

      The penetrance and severity of the ectopic tracheal migration phenotype is increased in PurAA17/+ shi2 double mutant embryos compared to either single mutant.

      The opposing tracheal phenotypes of PurAA17/+ and btlH82Δ3/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in PurAA17/+ btlH82Δ3/+ double heterozygous embryos.

      The opposing tracheal phenotypes of PurAA17/+ and Catsup26/+ single heterozygous embryos (ectopic migration and lack of migration respectively) are both partially suppressed in PurAA17/+ Catsup26/+ double heterozygous embryos.

      (Hsouna et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The viability in trans with other Pu alleles has been determined.

      (Mackay et al., 1985)

      Class II Pu allele.

      (Reynolds and O'Donnell, 1987)

      Class II allele.

      (O'Donnell et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PuAA17
      (Hsouna et al., 2007, Reynolds and O'Donnell, 1987)
      PurAA17
      Name Synonyms
      Secondary FlyBase IDs
        References (6)