FlyBase Allele Report: Dmel\Su(z)12[3]

General Information

Symbol

Dmel\Su(z)12³

Species

D. melanogaster

Name

FlyBase ID

FBal0094495

Feature type

allele

Associated gene

Dmel\Su(z)12

Associated Insertion(s)

Carried in Construct

Also Known As

l(3)76BDo¹

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kehle et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: W298term.

(Birve et al., 2001)

Nucleotide substitution: G?A.

(Birve et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:19,921,738..19,921,738 [-]

Nucleotide change:

G19921738A

Reported nucleotide change:

G?A

Amino acid change:

W298term | Su(z)12-PA; W298term | Su(z)12-PB

Reported amino acid change:

W298term

Comment:

TGG to TGA

(Birve et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Kehle et al., 1998)

lethal - all die before end of larval stage | recessive

(Birve et al., 2001)

some die during larval stage | recessive

(Birve et al., 2001)

suppressor of variegation | dominant, with In(1)w^m4

(Birve et al., 2001)

visible | homeotic | pharate adult stage (with Su(z)12⁵)

(Birve et al., 2001)

Phenotype Manifest In

antenna (with Su(z)12⁵)

(Birve et al., 2001)

haltere | ectopic (with Su(z)12⁵)

(Birve et al., 2001)

leg | ectopic (with Su(z)12⁵)

(Birve et al., 2001)

mesothoracic metatarsus (with Su(z)12⁵)

(Birve et al., 2001)

metathoracic metatarsus (with Su(z)12⁵)

(Birve et al., 2001)

sex comb | ectopic (with Su(z)12⁵)

(Birve et al., 2001)

wing (with Su(z)12⁵)

(Birve et al., 2001)

Detailed Description

Statement

Reference

Su(z)12⁵/Su(z)12³ animals develop into pharate adults with strong posteriorly directed homeotic transformations. Sex combs are present on the first tarsal segment of the meso- and metathoracic legs in males, the antennae are partially transformed into legs and the wings are much smaller than normal and are partially transformed into halteres. Eggs are not recovered from females carrying homozygous germ-line clones.

(Birve et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Su(z)12³/Su(z)12[+] is a non-enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Su(z)12³/Su(z)12[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a suppressor of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)12³ is a suppressor of visible phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

NOT Suppressor of

Statement

Reference

Su(z)12³/Su(z)12[+] is a non-suppressor of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Su(z)12³/Su(z)12[+] is a non-enhancer of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Su(z)12³/Su(z)12[+] is a suppressor of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a suppressor of 1st posterior cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Su(z)12³ is a suppressor of eye phenotype of Scer\GAL4^lz-gal4, sens^UAS.cNa

(Anderson et al., 2011)

NOT Suppressor of

Statement

Reference

Su(z)12³/Su(z)12[+] is a non-suppressor of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

Su(z)12³/Su(z)12[+] is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The disorganised eye phenotype caused by expression of sens^Scer\UAS.cNa under the control of Scer\GAL4^lz-gal4 is suppressed by Su(z)12³.

(Anderson et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Su(z)12^daed

(Zirin and Mann, 2004)

Su(z)12¹

(Birve et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5068

Su(z)12³ red¹ e^*/TM6B, Sb¹ Tb⁺ ca¹

Kyoto

108016

Su(z)12³ red¹ e^*/TM6B, Sb¹ Tb¹ ca¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Su(z)12³

(Ponrathnam et al., 2021, Song et al., 2018, Bengani et al., 2013, Debruhl et al., 2013, Rai et al., 2013, Vasanthi et al., 2013, Ji et al., 2012, Anderson et al., 2011, Zhang et al., 2008, Sengupta et al., 2004)

l(3)76BDo¹

(Zhu et al., 2005, Kehle et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close