FlyBase Allele Report: Dmel\dsh[hs.sev.B]

General Information

Symbol

Dmel\dsh^hs.sev.B

Species

D. melanogaster

Name

FlyBase ID

FBal0093042

Feature type

allele

Associated gene

Dmel\dsh

Associated Insertion(s)

Carried in Construct

P{sE-Dsh.B}

Also Known As

sev-Dsh

Key Links

Transgenic product class

cDNA

(Boutros et al., 1998)

wild_type

(Boutros et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Boutros et al., 1998)

wild_type

(Boutros et al., 1998)

Mutagen

in vitro construct

(Boutros et al., 1998)

Progenitor genotype

Carried in construct

P{sE-Dsh.B}

Cytology

Description

Expression of dsh cDNA is driven by an Hsp70 promoter and sev enhancer.

(Boutros et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

dsh

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Weber et al., 2012, Weber et al., 2008, Pazman et al., 2000, Fanto and Mlodzik, 1999, Paricio et al., 1999)

abnormal planar polarity | dominant | heat sensitive

(Boutros et al., 1998)

wild-type

(Boutros et al., 1998)

Phenotype Manifest In

ommatidium

(Weber et al., 2012, Weber et al., 2008, Fanto and Mlodzik, 1999, Paricio et al., 1999)

ommatidium | heat sensitive

(Boutros et al., 1998)

photoreceptor cell R4

(Fanto and Mlodzik, 1999)

Detailed Description

Statement

Reference

Expression of dsh^hs.sev.B results in ommatidial orientation defects in the eye.

(Weber et al., 2012)

Expression of dsh^hs.sev.B results in 42% of adult ommatidia having a symmetrical arrangement.

(Weber et al., 2008)

Ommatidial arrangement is disrupted due to overactivation of planar polarity signalling.

(Paricio et al., 1999)

Eyes of flies raised at 29^oC show disruption of ommatidial arrangement with random or no chirality and misrotations of single ommatidia.

(Boutros et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dsh^hs.sev.B has visible phenotype, enhanceable by ex[+]/ex^e1

(Blaumueller and Mlodzik, 2000)

dsh^hs.sev.B has abnormal planar polarity phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fanto and Mlodzik, 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, enhanceable by N[+]/N^264-39

(Fanto and Mlodzik, 1999)

NOT Enhanced by

Statement

Reference

dsh^hs.sev.B has abnormal planar polarity phenotype, non-enhanceable by dock³

(Paricio et al., 1999)

Suppressed by

Statement

Reference

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(2L)ED793/+

(Weber et al., 2012)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by +/Df(3R)ED5644

(Weber et al., 2012)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by CG15283^GD13108/Scer\GAL4^hs.2sev

(Weber et al., 2012)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by kay¹/kay[+]

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by kay^ED6315/kay[+]

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Jra¹/Jra[+]

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Jra^IA109/Jra[+]

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by aop^yan-XE18/aop[+]

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by aop[+]/aop^e2d

(Weber et al., 2008)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(1)H6/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(1)G24/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(2L)flp170B/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(3R)crb87-4/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(2L)b80e3/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(3R)p13/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(3R)crb-F89-4/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by Df(2L)b87e25/+

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by hep[+]/hep^r75

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by msn[+]/msn¹⁰²

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by msn¹⁷²/msn[+]

(Paricio et al., 1999)

dsh^hs.sev.B has abnormal planar polarity phenotype, suppressible by bsk²/bsk[+]

(Paricio et al., 1999)

NOT suppressed by

Statement

Reference

dsh^hs.sev.B has abnormal planar polarity phenotype, non-suppressible by dock³

(Paricio et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

dsh^hs.sev.B has ommatidium phenotype, enhanceable by ex[+]/ex^e1

(Blaumueller and Mlodzik, 2000)

dsh^hs.sev.B has eye photoreceptor cell phenotype, enhanceable by ex[+]/ex^e1

(Blaumueller and Mlodzik, 2000)

dsh^hs.sev.B has eye phenotype, enhanceable by ex[+]/ex^e1

(Blaumueller and Mlodzik, 2000)

dsh^hs.sev.B has photoreceptor cell R4 phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fanto and Mlodzik, 1999)

dsh^hs.sev.B has ommatidium phenotype, enhanceable by Delta^RevF10/Dl[+]

(Fanto and Mlodzik, 1999)

dsh^hs.sev.B has photoreceptor cell R4 phenotype, enhanceable by N[+]/N^264-39

(Fanto and Mlodzik, 1999)

dsh^hs.sev.B has ommatidium phenotype, enhanceable by N[+]/N^264-39

(Fanto and Mlodzik, 1999)

NOT Enhanced by

Statement

Reference

dsh^hs.sev.B has phenotype, non-enhanceable by rin^unspecified

(Pazman et al., 2000)

dsh^hs.sev.B has ommatidium phenotype, non-enhanceable by dock³

(Paricio et al., 1999)

Suppressed by

Statement

Reference

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(2L)ED793/+

(Weber et al., 2012)

dsh^hs.sev.B has ommatidium phenotype, suppressible by +/Df(3R)ED5644

(Weber et al., 2012)

dsh^hs.sev.B has ommatidium phenotype, suppressible by CG15283^GD13108/Scer\GAL4^hs.2sev

(Weber et al., 2012)

dsh^hs.sev.B has ommatidium phenotype, suppressible by kay¹/kay[+]

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by kay^ED6315/kay[+]

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Jra¹/Jra[+]

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Jra^IA109/Jra[+]

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by aop^yan-XE18/aop[+]

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by aop[+]/aop^e2d

(Weber et al., 2008)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(1)H6/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(1)G24/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(2L)flp170B/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(3R)crb87-4/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(2L)b80e3/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(3R)p13/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(3R)crb-F89-4/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by Df(2L)b87e25/+

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by hep[+]/hep^r75

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by msn[+]/msn¹⁰²

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by msn¹⁷²/msn[+]

(Paricio et al., 1999)

dsh^hs.sev.B has ommatidium phenotype, suppressible by bsk²/bsk[+]

(Paricio et al., 1999)

dsh^hs.sev.B has phenotype, suppressible by Jra¹

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, suppressible by Jra^IA109

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, suppressible by Rho1^k07903

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, suppressible by bsk²

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, suppressible by hep^r75

(Boutros et al., 1998)

NOT suppressed by

Statement

Reference

dsh^hs.sev.B has phenotype, non-suppressible by rin^unspecified

(Pazman et al., 2000)

dsh^hs.sev.B has ommatidium phenotype, non-suppressible by dock³

(Paricio et al., 1999)

dsh^hs.sev.B has phenotype, non-suppressible by Cdc42³

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by Ras85D^e2F

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by arm²

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by arm⁸

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by pan^ER1

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by rl¹⁰

(Boutros et al., 1998)

dsh^hs.sev.B has phenotype, non-suppressible by wg^l-17

(Boutros et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The dsh^hs.sev.B gain-of-function planar cell polarity (PCP)-phenotype is markedly suppressed by the expression of CG15283^GD13108 via Scer\GAL4^hs.2sev.

(Weber et al., 2012)

One copy of kay¹, kay^ED6315, Jra¹ or Jra^IA109 suppresses the formation of symmetrical ommatidia that is seen in animals expressing dsh^hs.sev.B.

One copy of aop^yan-XE18 or aop^e2d partially suppresses the formation of symmetrical ommatidia that is seen in animals expressing dsh^hs.sev.B.

(Weber et al., 2008)

The eye phenotype seen in dsh^hs.sev.B flies is dominantly enhanced by the addition of ex^e1 due to an increase in unscorable ommatidia (missing one or more photoreceptors.

(Blaumueller and Mlodzik, 2000)

The tissue polarity phenotype of flies carrying dsh^hs.sev.B is dominantly enhanced by N^264-39 or Dl^RevF10; the percentage of symmetrical ommatidia containing an R3/R3 pair in the normal R3/R4 position is increased.

(Fanto and Mlodzik, 1999)

The ommatidial polarity defects seen in dsh^hs.sev.B flies grown at 29^oC can be dominantly suppressed by the addition of hep^r75, msn¹⁰², msn¹⁷², bsk², Df(1)H6, Df(1)G24, Df(2L)flp170B, Df(3R)crb87-4, Df(2L)b80e3, Df(3R)p13, Df(3R)crb-F89-4 and Df(2L)b87e25. Between 70-90% of ommatidia are in their correct polarity, compared with 55% in dsh^hs.sev.B alone. The ommatidial polarity defects seen in dsh^hs.sev.B flies grown at 29^oC are not suppressed by the addition of dock³.

(Paricio et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

dsh^hs.sev.B rescues dsh¹

(Boutros et al., 1998)

dsh^hs.sev.B rescues dsh³

(Boutros et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dsh^hs.sev.B

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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