FlyBase Allele Report: Dmel\rl[10]

General Information

Symbol

Dmel\rl¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0014596

Feature type

allele

Associated gene

Dmel\rl

Associated Insertion(s)

Carried in Construct

Also Known As

rl^EMS698, rl⁶⁹⁸

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hilliker, 1976)

Progenitor genotype

Caused by aberration

Df(2R)rl10a

Cytology

Description

Point mutation.

(Hilliker, 1976)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance

modeled by Graf¹

(Kim et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | recessive

(Inoue and Glover, 1998)

decreased cell number | third instar larval stage (with rl¹)

(Kim et al., 2017)

decreased occurrence of cell division | larval stage (with rl^10a)

(Inoue and Glover, 1998)

lethal | recessive

(Inoue and Glover, 1998)

Phenotype Manifest In

hemocyte | third instar larval stage (with rl¹)

(Kim et al., 2017)

macrochaeta

(Diaz-Benjumea and Hafen, 1994)

neuroblast | larval stage (with rl^10a)

(Inoue and Glover, 1998)

wing vein

(Diaz-Benjumea and Hafen, 1994)

wing vein | ectopic

(Diaz-Benjumea and Hafen, 1994)

Detailed Description

Statement

Reference

rl¹/rl¹⁰ mutant third instar larvae have significantly reduced concentration of circulating hemocytes compared to wild-type controls.

(Kim et al., 2017)

rl¹⁰/rl^10a heterozygotes die at the late third instar to pupal stage. Mitotic index of rl¹⁰/rl^10a larval neuroblasts is clearly reduced compared to wild type. The reduction is typical of a delay in passing through interphase, as a consequence of a reduced ability to transduce proliferation signals. The ratio of metaphase to anaphase figures is elevated, suggesting the cells are being delayed at metaphase. There is a low but significant level of hypercondensed chromosomes in both anaphase and metaphase. Some anaphase defects can be seen including a low frequency of overcondensed chromatids at late anaphase, anaphase figures with lagging chromatids and randomly oriented chromatids at anaphase. In contrast to wild type, there is very little increase in the mitotic index in either rl⁹/rl^10a or rl¹⁰/rl^10a mutants after colchicine treatment for 3 hrs, and over-condensation of the chromosomes is not seen.

(Inoue and Glover, 1998)

Clonal analysis reveals phenotypes in the adult including loss of wing vein, ectopic wing vein, reduced cell size, cell lethality and tergite bristle abnormalities.

(Diaz-Benjumea and Hafen, 1994)

Hemizygous larvae completely lack imaginal discs and die. Individuals die as pupae when heterozygous with rl¹ or rl⁶.

(Hilliker, 1976)

L3 larval lethal as hemizygote no imaginal discs pupal lethal when heterozygous with rl¹ or rl⁶ (Hilliker, 1976).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

rl¹⁰ is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

rl¹/rl¹⁰ is a suppressor of abnormal neuroanatomy | adult stage phenotype of Graf¹

(Kim et al., 2021)

rl¹/rl¹⁰ is a suppressor of increased cell number | third instar larval stage phenotype of Graf¹

(Kim et al., 2017)

rl[+]/rl¹⁰ is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Fak^RNAi.UAS, Scer\GAL4^elav.PU

(Tsai et al., 2008)

NOT Suppressor of

Statement

Reference

rl¹⁰ is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

rl¹⁰ is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dsh^UAS.cNa

(Strutt et al., 1997)

rl¹⁰ is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, fz^UAS.cAa

(Strutt et al., 1997)

Other

Statement

Reference

Raf^Su2, rl¹⁰ has lethal phenotype

(Li et al., 2000)

Raf^Su2, rl[+]/rl¹⁰ has lethal phenotype

(Li et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

rl¹⁰ has phenotype, suppressible by bs⁰³²⁶⁷

(Roch et al., 1998)

NOT Enhancer of

Statement

Reference

rl¹⁰ is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Suppressor of

Statement

Reference

rl¹/rl¹⁰ is a suppressor of axon | adult stage phenotype of Graf¹

(Kim et al., 2021)

rl¹/rl¹⁰ is a suppressor of adult mushroom body beta-lobe phenotype of Graf¹

(Kim et al., 2021)

rl¹/rl¹⁰ is a suppressor of midline | adult stage phenotype of Graf¹

(Kim et al., 2021)

rl¹/rl¹⁰ is a suppressor of hemocyte | increased number | third instar larval stage phenotype of Graf¹

(Kim et al., 2017)

rl[+]/rl¹⁰ is a suppressor of neuromuscular junction | third instar larval stage phenotype of Fak^RNAi.UAS, Scer\GAL4^elav.PU

(Tsai et al., 2008)

rl[+]/rl¹⁰ is a suppressor of NMJ bouton | increased number | third instar larval stage phenotype of Fak^RNAi.UAS, Scer\GAL4^elav.PU

(Tsai et al., 2008)

rl¹⁰ is a suppressor of embryonic/first instar larval cuticle | maternal effect phenotype of tor^12D

(Li and Li, 2003)

rl[+]/rl¹⁰ is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

rl¹⁰ is a suppressor of phenotype of svp^2.sev

(Begemann et al., 1995)

rl¹⁰ is a suppressor of phenotype of svp^1.sev

(Begemann et al., 1995)

rl¹/rl¹⁰ is a suppressor of phenotype of tor^11D

(Brunner et al., 1994)

NOT Suppressor of

Statement

Reference

rl¹⁰ is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

rl¹⁰ is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

rl¹⁰ is a non-suppressor of phenotype of dsh^hs.sev.B

(Boutros et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The increased concentration of circulating hemocytes characteristic for Graf¹/Y mutant third instar larvae is suppressible by combination rl¹/rl¹⁰, which reduces the hemocyte levels in Graf¹/Y larvae to below wild-type levels, comparable to those seen in rl¹/rl¹⁰ single mutants.

(Kim et al., 2017)

rl¹⁰/+ completely suppresses the overgrowth of the neuromuscular junction (increased bouton number per muscle area and increased NMJ length per muscle area) seen in third instar larvae expressing Fak^{dsRNA.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Tsai et al., 2008)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Does not alter the eye tissue polarity phenotype produced by either fz^Scer\UAS.cAa or dsh^Scer\UAS.cNa expressed under the control of Scer\GAL4^hs.2sev.

(Strutt et al., 1997)

Suppressor of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

rl¹/rl¹⁰ suppresses the mutant phenotype of embryos derived from tor^11D mothers.

(Brunner et al., 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Hilliker.

Comments

Phenotypes of rl mutants fall into an allelic series: Df(2R)rl10a/rl¹ >= rl⁹/rl¹ > rl^la8/rl¹ > rl¹⁰/rl¹ > rl¹/rl¹.

(Diaz-Benjumea and Hafen, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

EMS698

(Hilliker, 1976)

l(2)EMS698

(Eberl et al., 1993)

rl/MAPK^EMS698

(Begemann et al., 1995)

rl¹⁰

(Kim et al., 2021, Kim et al., 2017, Galindo et al., 2005)

rl⁶⁹⁸

(Fanto, 2000, Fanto et al., 2000, Li et al., 2000, Zhang et al., 1999, Inoue and Glover, 1998)

rl^EMS698

(Yan et al., 2010, Tsai et al., 2008, Zhu et al., 2005, Li and Li, 2003, Li et al., 2000, Strutt et al., 1997, Brunner et al., 1994, Diaz-Benjumea and Hafen, 1994)

rl^ems698

(Roch et al., 1998)

rolled⁶⁹⁸

(Boutros et al., 1998)

Name Synonyms

Secondary FlyBase IDs

References (20)

Report Sections

Open Close