FlyBase Allele Report: Scer\GAL4[FMRFa.PS]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Scer\GAL4^FMRFa.PS

General Information

Symbol

Scer\GAL4^FMRFa.PS

Species

S. cerevisiae

Name

FMRFamide-related promoter construct of Schubiger

FlyBase ID

FBal0090645

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{FMRFa-GAL4.S}

Also Known As

FMRF-GAL4, FMRFa-GAL4

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Suster et al., 2003, Schubiger et al., 1998)

Progenitor genotype

Carried in construct

P{FMRFa-GAL4.S}

Cytology

Description

Approximately 5.5kb of FMRFa regulatory sequences (nucleotides -4973 to +50 of exon I) regulates expression of a GAL4 driver.

(Suster et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Bloomington Drosophila Stock Center, 2017)

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Bloomington Drosophila Stock Center, 2017)

FMRFamide SE2 neuron

(Bloomington Drosophila Stock Center, 2017)

FMRFamide SE3 neuron

(Bloomington Drosophila Stock Center, 2017)

prepupal stage P1 -- P4

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Schubiger et al., 1998)

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Kim et al., 2006)

Additional Information

Statement

Reference

ScerGAL4^FMRFa.PS drives expression in FMRFa-expressing neurons.

(Bloomington Drosophila Stock Center, 2017)

ScerGAL4^FMRFa.PS drives expression in a very specific subset of FMRFa-expressing neurons, the three pairs of apterous-expressing neuron of the lateral cluster of the thorax Ap4, as well as in a single pair of unidentified neurons in the subesophageal ganglion.

(Kim et al., 2006)

ScerGAL4^FMRFa.PS drives expression in apterous-expressing neuron of the lateral cluster of the thorax Ap4 (Tv neurons) during prepupal stages.

(Schubiger et al., 1998)

Marker for

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Kim et al., 2006)

Reflects expression of

(Bloomington Drosophila Stock Center, 2017, Kim et al., 2006, Schubiger et al., 1998)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with EcR^{A-ΔC655.F645A.UAS}

(Brown et al., 2006)

abnormal neuroanatomy, with EcR^{A-ΔC655.W650A.UAS}

(Brown et al., 2006)

abnormal neuroanatomy, with EcR^{B1-ΔC655.F645A.UAS}

(Brown et al., 2006)

abnormal neuroanatomy, with EcR^{B1-ΔC655.W650A.UAS}

(Brown et al., 2006)

abnormal neuroanatomy, with EcR^{B2-ΔC655.W650A.UAS}

(Brown et al., 2006)

Phenotype Manifest In

apterous-expressing neuron of the lateral cluster of the thorax Ap4, with rpr^UAS.cZa

(Kim et al., 2006)

mesothoracic ventral neurosecretory neuron & axon, with EcR^{A-ΔC655.W650A.UAS}

(Brown et al., 2006)

mesothoracic ventral neurosecretory neuron & axon, with EcR^{B1-ΔC655.F645A.UAS}

(Brown et al., 2006)

mesothoracic ventral neurosecretory neuron & axon, with EcR^{B1-ΔC655.W650A.UAS}

(Brown et al., 2006)

mesothoracic ventral neurosecretory neuron & axon, with EcR^{B2-ΔC655.W650A.UAS}

(Brown et al., 2006)

metathoracic ventral thoracic neurosecretory neuron & axon, with EcR^{A-ΔC655.W650A.UAS}

(Brown et al., 2006)

metathoracic ventral thoracic neurosecretory neuron & axon, with EcR^{B1-ΔC655.F645A.UAS}

(Brown et al., 2006)

metathoracic ventral thoracic neurosecretory neuron & axon, with EcR^{B1-ΔC655.W650A.UAS}

(Brown et al., 2006)

metathoracic ventral thoracic neurosecretory neuron & axon, with EcR^{B2-ΔC655.W650A.UAS}

(Brown et al., 2006)

neurohemal organ, with EcR^{A-ΔC655.F645A.UAS}

(Brown et al., 2006)

neurohemal organ, with EcR^{A-ΔC655.W650A.UAS}

(Brown et al., 2006)

neurohemal organ, with EcR^{B1-ΔC655.F645A.UAS}

(Brown et al., 2006)

neurohemal organ, with EcR^{B1-ΔC655.W650A.UAS}

(Brown et al., 2006)

neurohemal organ, with EcR^{B2-ΔC655.W650A.UAS}

(Brown et al., 2006)

prothoracic ventral neurosecretory neuron & axon, with EcR^{A-ΔC655.W650A.UAS}

(Brown et al., 2006)

prothoracic ventral neurosecretory neuron & axon, with EcR^{B1-ΔC655.F645A.UAS}

(Brown et al., 2006)

prothoracic ventral neurosecretory neuron & axon, with EcR^{B1-ΔC655.W650A.UAS}

(Brown et al., 2006)

prothoracic ventral neurosecretory neuron & axon, with EcR^{B2-ΔC655.W650A.UAS}

(Brown et al., 2006)

Tv neuron & axon, with EcR^{A-ΔC655.F645A.UAS}

(Brown et al., 2006)

Tv neuron & axon, with EcR^{RNAi.B1.UAS.cSa}

(Brown et al., 2006)

Tv neuron & filopodium, with EcR^{RNAi.B1.UAS.cSa}

(Brown et al., 2006)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

Scer\GAL4^FMRFa.PS/EcR^A.UAS partially rescues EcR⁹⁹/EcR³¹

(Schubiger et al., 2003)

Scer\GAL4^FMRFa.PS/EcR^B2.UAS partially rescues EcR⁹⁹/EcR³¹

(Schubiger et al., 2003)

EcR^B1.UAS/Scer\GAL4^FMRFa.PS partially rescues EcR⁹⁹/EcR³¹

(Schubiger et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

56837

w¹¹¹⁸; P{FMRFa-GAL4.S}FG5

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

FMRFa^GAL4

(Song et al., 2023)

GAL4^Fmrf.PS

Scer\GAL4^FMRFa.PS

Scer\GAL4^Fmrf.PS

Name Synonyms

FMRFamide-related promoter construct of Schubiger

(Schubiger et al., 1998)

Secondary FlyBase IDs

References (12)

Report Sections