FB2024_03 , released June 25, 2024
Allele: Dmel\EcRRNAi.B1.UAS.cSa
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General Information
Symbol
Dmel\EcRRNAi.B1.UAS.cSa
Species
D. melanogaster
Name
FlyBase ID
FBal0189736
Feature type
allele
Associated gene
Dmel\EcR
Associated Insertion(s)
Carried in Construct
P{UAS-EcR.RNAi.S}
Key Links
Transgenic product class
RNAi_reagent
(Brown et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Brown et al., 2006)
Mutagen
in vitro construct
(Brown et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-EcR.RNAi.S}
Cytology
Description

UAS sequences drive expression of an inverted repeat of the EcR-B1 isoform.

(Brown et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
EcR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      Tv neuron & axon, with Scer\GAL4FMRFa.PS

      (Brown et al., 2006)

      Tv neuron & filopodium, with Scer\GAL4FMRFa.PS

      (Brown et al., 2006)
      Detailed Description
      Statement
      Reference

      Larvae expressing EcRdsRNA.B1.Scer\UAS.cSa under the control of Scer\GAL4C-765 do not reach critical weight prematurely.

      (Mirth et al., 2009)

      Tv neurons expressing EcRdsRNA.B1.Scer\UAS.cSa under the control of Scer\GAL4Fmrf.PS, show normal larval neurohemal organs at pupariation, but by 24 hours APF, the neurons still have larval-like arbors, although such arbors are reduced in size compared with larval stages. There are no visible adult-like branches at 24 hours APF, but by 48 hours APF EcRdsRNA.B1.Scer\UAS.cSa-expressing neurons have a dense, clumped axon arbor that is surrounded by a reduced adult-like arbor. There are no filopodia during the normal pruning phase (12-18 hours APF); these first appear at 24-28 hours APF and form stable, fasciculated branches, resulting in an adult arbor with both larval and adult characteristics.

      (Brown et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      M. Schubiger

      (Brown et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EcRRNAi.B1.UAS.cSa
      EcRdsRNA.B1.Scer\UAS.cSa
      EcRdsRNA.B1.UAS.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)