FlyBase Allele Report: Dmel\Med[13]

General Information

Symbol

Dmel\Med¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0090597

Feature type

allele

Associated gene

Dmel\Med

Associated Insertion(s)

Carried in Construct

Also Known As

Medea¹³

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hudson et al., 1998)

Progenitor genotype

Cytology

Description

Amino acid replacement: ?66term.

(Xu et al., 1998)

Nucleotide position refers to cDNAs 29 and O513.

(Xu et al., 1998)

Nucleotide substitution: C814T.

(Xu et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:31,612,110..31,612,110 [+]

Nucleotide change:

C31612110T

Reported nucleotide change:

C814T

Amino acid change:

R66term | Med-PA; R66term | Med-PB; R66term | Med-PC

Reported amino acid change:

?66term

(Xu et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates muscular dystrophy

modeled by Scgδ⁸⁴⁰

(Goldstein et al., 2011)

ameliorates cardiomyopathy

modeled by Scgδ⁸⁴⁰

(Goldstein et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Med¹³ suppresses the heart tube dysfunction component of muscular dystrophy in Scgδ⁸⁴⁰ flies, as well as muscle dysfunction.

(Goldstein et al., 2011)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with Med¹)

(Cook, 2006.1.31)

lethal (with Med⁵)

(Cook, 2006.1.31)

lethal (with Med^adro)

(Zirin and Mann, 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Eggs laid by females containing large homozygous follicle cell clones lack dorsoventral eggshell polarity. The region surrounding the micropyle is reduced in size and lacks follicle cell imprints.

(Shravage et al., 2007)

Med¹³ mutant clones display defects in dorsal cluster neurons but do not exhibit remodeling defects in γ mushroom body neurons.

(Zheng et al., 2006)

Lethal in trans with Med¹², Med¹¹, Med¹⁴, Med¹⁶, Med¹⁸ or Df(3R)E40. Med¹³/Med¹⁵ flies lack the posterior crossvein and have a large discontinuity in wing vein L4. Females containing homozygous Med¹³ germ line clones mated to Med¹⁴/+ males produce eggs of two phenotypic classes: 48% have a partially ventralised phenotype (presumptive zygotic genotype Med¹³/+) characterised by the presence of dorsal hairs, internalisation of filzkorper and elimination of dorsolaterally derived structures of the head. The second class of embryos (presumptive zygotic genotype Med¹³/Med¹⁴) do not differentiate any dorsal structures, but instead differentiate ventral denticle bands around the entire embryonic circumference. These embryos do not differentiate amnioserosa.

(Hudson et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Med¹³/Med[+] is an enhancer of lethal | recessive | partially phenotype of sog^P129D

(Decotto and Ferguson, 2001)

Suppressor of

Statement

Reference

Med¹³/Med[+] is a suppressor of abnormal locomotor behavior | adult stage phenotype of Scgδ⁸⁴⁰

(Goldstein et al., 2011)

Other

Statement

Reference

Med¹³, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Phenotype Manifest In

Enhancer of

Statement

Reference

Med¹³/Med[+] is an enhancer of phenotype of dpp^hr4

(Hudson et al., 1998)

Suppressor of

Statement

Reference

Med¹³/Med[+] is a suppressor of adult heart phenotype of Scgδ⁸⁴⁰

(Goldstein et al., 2011)

Other

Statement

Reference

Med¹³, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ⁸⁴⁰ mutants is suppressed if the flies are also carrying Med¹³/+.

The dilated heart tube seen in Scgδ⁸⁴⁰ adults (detected as increased end-systolic and end-diastolic diameters as measured by optical coherence tomography) is rescued if the flies are carrying Med¹³/+.

(Goldstein et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Med¹

(Cook, 2006.1.31)

Med⁵

(Cook, 2006.1.31)

Med^ES2

(Decotto and Ferguson, 2001)