FlyBase Allele Report: Dmel\Scgδ[840]

General Information

Symbol

Dmel\Scgδ⁸⁴⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0221042

Feature type

allele

Associated gene

Dmel\Scgδ

Associated Insertion(s)

Carried in Construct

Also Known As

Sgcd⁸⁴⁰

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Allikian et al., 2007)

Progenitor genotype

P{SUPor-P}Scgδ^KG05430

(Allikian et al., 2007)

Cytology

Description

Imprecise excision of the P{SUPor-P}Scgδ^KG05430 insertion, resulting in a deletion of approximately 6.5kb which extends from the original insertion site upstream of Scgδ exon 1 through exon 4.

(Allikian et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of muscular dystrophy

CEA

(Vanhoutte et al., 2016, Gao et al., 2015, Goldstein et al., 2011, Allikian et al., 2007)

model of cardiomyopathy

CEA

(Goldstein et al., 2011)

model of dilated cardiomyopathy 1L

CEA

(Allikian et al., 2007)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of muscular dystrophy

is ameliorated by Med¹³

(Goldstein et al., 2011)

is ameliorated by Mad¹²

(Goldstein et al., 2011)

is ameliorated by Med¹⁷

(Goldstein et al., 2011)

is ameliorated by Smox^G0348

(Goldstein et al., 2011)

is ameliorated by Med¹⁵

(Goldstein et al., 2011)

is ameliorated by Mmus\Sgcg^{mini.UAS.Tag:Xpress}

(Gao et al., 2015)

is ameliorated by Mmus\Thbs4^UAS.cVa

(Vanhoutte et al., 2016)

is ameliorated by Tsp^UAS.AD.cSa

(Vanhoutte et al., 2016)

model of cardiomyopathy

is ameliorated by Med¹³

(Goldstein et al., 2011)

is ameliorated by Smox^G0348

(Goldstein et al., 2011)

is NOT ameliorated by Mad¹²

(Goldstein et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Goldstein et al., 2011)

short lived

(Allikian et al., 2007)

Phenotype Manifest In

adult heart

(Goldstein et al., 2011, Allikian et al., 2007)

dorsal longitudinal indirect flight muscle cell

(Allikian et al., 2007)

indirect flight muscle cell

(Goldstein et al., 2011)

M band

(Allikian et al., 2007)

sarcomere

(Allikian et al., 2007)

Detailed Description

Statement

Reference

Mutant adults do not spend as much time in flight as wild-type controls when housed in a 20cm[3] box to permit ad libitum flight, but the amount of flight is sufficient to induce injury in the indirect flight muscles; muscle disruption is occasionally apparent in non-exercised mutant flies, but muscle tears in the indirect flight muscles are larger and more frequently seen in the exercised flies housed in the 20cm[3] box. Very rarely, infiltration of non-muscle cells that resemble hemocytes into the indirect flight muscles is seen in the exercised flies.

Mutant flies show age-dependent severe loss of climbing ability in a negative geotaxis assay.

The end-systolic and end-diastolic diameters of the heart as measured by optical coherence tomography are increased in the mutant adults compared to controls (indicating a dilated heart tube).

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ mutants present a decreased adult lifespan, as compared to controls.

(Allikian et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scgδ⁸⁴⁰ has abnormal locomotor behavior | adult stage phenotype, suppressible by Mad¹²/Mad[+]

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ has abnormal locomotor behavior | adult stage phenotype, suppressible by Med[+]/Med¹⁵

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ has abnormal locomotor behavior | adult stage phenotype, suppressible by Med¹³/Med[+]

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ has abnormal locomotor behavior | adult stage phenotype, suppressible by Med¹⁷/Med[+]

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ has abnormal locomotor behavior | adult stage phenotype, suppressible by Smox^G0348/Smox[+]

(Goldstein et al., 2011)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scgδ⁸⁴⁰ has adult heart phenotype, suppressible by Smox^G0348/Smox[+]

(Goldstein et al., 2011)

Scgδ⁸⁴⁰ has adult heart phenotype, suppressible by Med¹³/Med[+]

(Goldstein et al., 2011)

NOT suppressed by

Statement

Reference

Scgδ⁸⁴⁰ has adult heart phenotype, non-suppressible by Mad¹²/Mad[+]

(Goldstein et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ⁸⁴⁰ mutants is suppressed if the flies are also carrying either Smox^G0348/+, Mad¹²/+, Med¹³/+, Med¹⁷/+ or Med¹⁵/+.

The dilated heart tube seen in Scgδ⁸⁴⁰ adults (detected as increased end-systolic and end-diastolic diameters as measured by optical coherence tomography) is rescued if the flies are carrying either Smox^G0348/+ or Med¹³/+, but is not rescued if the flies are carrying Mad¹²/+.

(Goldstein et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Line 840

(Allikian et al., 2007)

Scgδ⁸⁴⁰

Sgcd⁸⁴⁰

(Vanhoutte et al., 2016, Gao et al., 2015, Goldstein et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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