FlyBase Allele Report: Dmel\zen[1]

General Information

Symbol

Dmel\zen¹

Species

D. melanogaster

Name

FlyBase ID

FBal0018855

Feature type

allele

Associated gene

Dmel\zen

Associated Insertion(s)

Carried in Construct

Also Known As

zen^f16

Key Links

Allele class

heat sensitive loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive loss of function allele

(Wakimoto et al., 1984)

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Arora and Nusslein-Volhard, 1992)

lethal - all die during embryonic stage | heat sensitive

(Wakimoto et al., 1984)

some die during embryonic stage | heat sensitive

(Wakimoto et al., 1984)

viable

(Hudson et al., 1998)

Phenotype Manifest In

adult optic lobe

(Wakimoto et al., 1984)

embryonic head

(Wakimoto et al., 1984)

Detailed Description

Statement

Reference

98% of homozygous embryos hatch at 25^oC.

(Decotto and Ferguson, 2001)

98% of homozygous embryos hatch.

(Hudson et al., 1998)

Weak ventralised phenotype.

(Arora and Nusslein-Volhard, 1992)

Head involution does not occur in zen¹ hemizygotes raised at the restrictive temperature. Germ band elongation is often normal. The optic lobe is absent. Viability is reduced at the permissive temperature.

(Wakimoto et al., 1984)

temperature-sensitive

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

sog^P129D, zen¹ has lethal | recessive | embryonic stage phenotype

(Decotto and Ferguson, 2001)

Med¹⁴, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹⁵, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹⁶, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹⁷, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹⁸, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Mad^Ez, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹¹, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹², zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Med¹³, zen¹ has lethal | recessive | embryonic stage phenotype

(Hudson et al., 1998)

Phenotype Manifest In

Other

Statement

Reference

sog^P129D, zen¹ has embryonic/first instar larval cuticle phenotype

(Decotto and Ferguson, 2001)

Med¹⁴, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹⁵, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹⁶, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹⁷, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹⁸, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Mad^Ez, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹¹, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹², zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Med¹³, zen¹ has embryonic/first instar larval cuticle phenotype

(Hudson et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

sog^P129D ; zen¹ double mutant embryos die with a partially ventralised phenotype at 25^oC.

(Decotto and Ferguson, 2001)

The zen¹ phenotype is dominantly maternally enhanced by Med¹¹, Med¹², Med¹³, Med¹⁴, Med¹⁵, Med¹⁶, Med¹⁷, Med¹⁸ or Mad^Ez; in females carrying any of these mutations, 75-100% of zen¹/zen¹ progeny die as embryos with a partially ventralised cuticular phenotype.

(Hudson et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2261

zen¹ p^p/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Fornili.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

f16^ts

(Wakimoto et al., 1984)

zen¹

(Becker et al., 2016)

zen^f16

(Hudson et al., 1998, Hudson et al., 1995, Arora and Nusslein-Volhard, 1992, Wakimoto et al., 1984)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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