FlyBase Allele Report: Dmel\if[SEF]

General Information

Symbol

Dmel\if^SEF

Species

D. melanogaster

Name

FlyBase ID

FBal0089181

Feature type

allele

Associated gene

Dmel\if

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bloor and Brown, 1998)

Progenitor genotype

Cytology

Description

No sequence alteration compared to wild type has been found in the coding region or in the splice junctions.

(Devenport et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Bloor and Brown, 1998)

some die during embryonic stage | recessive

(Bloor and Brown, 1998)

viable (with if^2B1)

(Devenport et al., 2007)

viable (with if^C2B)

(Devenport et al., 2007)

Phenotype Manifest In

actin cytoskeleton | embryonic stage 17

(Devenport et al., 2007)

embryonic/larval somatic muscle cell | embryonic stage 17

(Devenport et al., 2007)

larval ventral nerve cord

(Bloor and Brown, 1998)

presumptive embryonic/larval muscle system

(Jani and Schock, 2007)

sarcomere & somatic muscle

(Bloor and Brown, 1998)

somatic muscle cell

(Bloor and Brown, 1998)

Detailed Description

Statement

Reference

Mutant embryos show a strong cytoskeletal detachment phenotype in the somatic muscles. The defect is first seen at stage 17, when the actin within the muscles retracts from the muscle ends. Mutant embryos have no midgut defects.

(Devenport et al., 2007)

Hemizygous embryos do not show muscle detachment at stage 16, but at stage 17, 100% of the embryos show a muscle detachment phenotype.

(Jani and Schock, 2007)

Defects in the structure of the sarcomeres within the striated somatic muscles. Nerve cord is not fully condensed. Midgut morphogenesis occurs normally and the vast majority of muscles remain attached to the epidermis. Mutants are unable to form normal contractile somatic muscles. 80% of double heterozygotes with mys^xR04 survive.

(Bloor and Brown, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

if^SEF has presumptive embryonic/larval muscle system phenotype, enhanceable by Zasp[+]/Zasp52^Δ

(Jani and Schock, 2007)

NOT Enhanced by

Statement

Reference

if^SEF has presumptive embryonic/larval muscle system phenotype, non-enhanceable by Zasp52^f04784/CG30084[+]

(Jani and Schock, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The muscle detachment phenotype seen in if^SEF embryos is more severe and appears at an earlier stage if the embryos also carry Zasp^Δ/+. Heterozygosity for Zasp^f04784 does not enhance the muscle detachment phenotype of if^SEF embryos.

(Jani and Schock, 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

if^2B1

(Bloor and Brown, 1998)

if^C2B

(Bloor and Brown, 1998)

if³

(Bloor and Brown, 1998)