FB2024_03 , released June 25, 2024
Allele: Dmel\if17
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General Information
Symbol
Dmel\if17
Species
D. melanogaster
Name
FlyBase ID
FBal0089214
Feature type
allele
Associated gene
Dmel\if
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Bloor and Brown, 1998)
Mutagen
ethyl methanesulfonate
(Bloor and Brown, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: D309N.

(Devenport et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,756,846..16,756,846 [-]
Nucleotide change:

G16756846A

Amino acid change:

D340N | if-PB; D315N | if-PC; D340N | if-PD; D340N | if-PF

Reported amino acid change:

D309N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change, which was reported in the context of the surrounding amino acid sequence.

(Devenport et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos show a weak cytoskeletal detachment phenotype in the somatic muscles. The defect is first seen at stage 17, when the actin within the muscles retracts from the muscle ends.

      (Devenport et al., 2007)

      Embryos exhibit normal epidermis and resultant secreted cuticle, defects lie in internal tissues. Somatic muscle detach and round up. Many muscles show a disturbed sarcomeric structure. Integrity of the visceral muscle layer is disturbed, sarcomeric structure is normal. Gut morphogenesis is defective: anterior midgut does not become a slender tube and only two fat gastric caecae are formed. The ventral nerve cord does not fully condense. 23% of double heterozygotes with mysxR04 survive.

      (Bloor and Brown, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: F2 against Dp(1;4)80f3c.

      (Bloor and Brown, 1998)
      Comments
      Comments

      Class I mutation. Allelic series based on mutant phenotype of class I mutations: if13ts < if21 < if17 < if35.

      (Bloor and Brown, 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      if17
      (Devenport et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)